Preparation and Influencing Factors of Sirolimus Liposome by Supercritical Fluid

Wei Zhang; Yong Sun; Yongjian Li; Ruowu Shen; Hongli Ni; Dejian Hu

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Preparation and Influencing Factors of Sirolimus Liposome by Supercritical Fluid

机译：超临界流体制备西罗莫司脂质体及其影响因素

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We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.

机译：我们通过快速膨胀超临界流体的超临界溶液（RESS）技术制备西罗莫司脂质体，并研究了温度，压力和平衡时间对脂质体平均粒径和包封率的影响。脂质体的最小平均粒径的条件分别是：温度328K（35MPa），压力35MPa（333K），平衡时间50分钟（343K）。脂质体的最大包封率的条件分别是温度333K（30MPa），压力35MPa（343K）和平衡50分钟（323K）。

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《Artificial cells, blood substitutes, and immobilization biotechnology.》 |2012年第2期|共4页
作者
Wei Zhang; Yong Sun; Yongjian Li; Ruowu Shen; Hongli Ni; Dejian Hu;
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中图分类生物医学工程;
关键词
supercritical fluidsirolimusliposomeRESS;

机译：超临界流体西罗莫司脂质体;

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1. Preparation and Influencing Factors of Sirolimus Liposome by Supercritical Fluid [J] . Wei Zhang, Yong Sun, Yongjian Li, Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第2期

机译：超临界流体制备西罗莫司脂质体及其影响因素
2. Preparation and influencing factors of sirolimus liposome by supercritical fluid [J] . ZhangW., SunY., LiY., Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第1a2期

机译：超临界流体制备西罗莫司脂质体及其影响因素
3. Preparation and influencing factors of sirolimus liposome by supercritical fluid. [J] . Wei Zhang, Yong Sun, Yongjian Li, Artificial cells, blood substitutes, and biotechnology . 2012,第1a2期

机译：超临界流体制备西罗莫司脂质体及其影响因素。
4. Preparation and Characterization of Metronidazole liposome by Supercritical Reverse Phase Evaporation Method [C] . Chen Shuhua, Liu Xuewu, Zhan Shiping, International Conference on Materials Science and Engineering . 2013

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6. Enhanced oral bioavailability of silymarin using liposomes containing a bile salt: preparation by supercritical fluid technology and evaluation in vitro and in vivo [O] . Gang Yang, Yaping Zhao, Yongtai Zhang, 2015

机译：使用含胆盐的脂质体提高水飞蓟素的口服生物利用度：通过超临界流体技术制备并在体内外进行评估
7. Influence of Modifiers on Supercritical Fluid Chromatography (SFC) and Supercritical Fluid Extraction (SFE), Part I [O] . Ilia Brondz, Boris Sedunov, Nagarajan Sivaraman 2017

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Preparation and Influencing Factors of Sirolimus Liposome by Supercritical Fluid

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