Fabrication of Capillary-like Network in a Matrix of Water-soluble Polymer Using Poly(methyl methacrylate) Microfibers

Takayuki Takei; Naoya Kishihara; Hiroyuki Ijima; Koei Kawakami

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Fabrication of Capillary-like Network in a Matrix of Water-soluble Polymer Using Poly(methyl methacrylate) Microfibers

机译：聚甲基丙烯酸甲酯超细纤维在水溶性聚合物基质中毛细管样网络的制备

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Poly(methyl methacrylate) (PMMA) microfibers were used as a template for development of a capillary-like network in agarose hydrogel. Microfibers with diameter 10-20 μm, which is comparable to the diameter of native capillary vessels, were fabricated using a wet spinning technique. The microfibers were embedded in agarose gel and dissolved by immersing the gel in dichloromethane. The resultant microchannels in the gel had the same diameter as the microfibers, and allowed an aqueous solution to be perfused through the gel. The methodology is promising for fabricating a capillary-like network in tissue engineering scaffolds of various water-soluble polymers.

机译：聚甲基丙烯酸甲酯（PMMA）超细纤维被用作琼脂糖水凝胶中毛细管状网络发展的模板。使用湿纺技术制造了直径为10-20μm的微纤维，该直径与天然毛细管的直径相当。将微纤维包埋在琼脂糖凝胶中，并通过将凝胶浸入二氯甲烷中使其溶解。凝胶中所得的微通道具有与微纤维相同的直径，并允许水溶液灌注通过凝胶。该方法有望在各种水溶性聚合物的组织工程支架中制造类似毛细管的网络。

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《Artificial cells, blood substitutes, and immobilization biotechnology.》 |2012年第2期|共4页
作者
Takayuki Takei; Naoya Kishihara; Hiroyuki Ijima; Koei Kawakami;
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中图分类生物医学工程;
关键词
capillary networkmicrofiberwater-soluble polymerscaffoldwet spinning techniquetissue engineering;

机译：毛细管网络微纤维水溶性高分子纤维湿法纺丝技术组织工程;

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1. Fabrication of capillary-like network in a matrix of water-soluble polymer using poly(methyl methacrylate) microfibers [J] . TakeiT., KishiharaN., IjimaH., Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第1a2期

机译：用聚甲基丙烯酸甲酯微纤维在水溶性聚合物基质中制备毛细管状网络
2. Fabrication of capillary-like network in a matrix of water-soluble polymer using poly(methyl methacrylate) microfibers. [J] . Takayuki Takei, Naoya Kishihara, Hiroyuki Ijima, Artificial cells, blood substitutes, and biotechnology . 2012,第1a2期

机译：使用聚（甲基丙烯酸甲酯）超细纤维在水溶性聚合物基质中制备毛细管状网络。
3. Fabrication of Capillary-like Network in a Matrix of Water-soluble Polymer Using Poly(methyl methacrylate) Microfibers [J] . Takayuki Takei, Naoya Kishihara, Hiroyuki Ijima Koei Kawakami Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第2期

机译：聚甲基丙烯酸甲酯超细纤维在水溶性聚合物基质中制备类毛细管网络
4. A comparison of the Deformation and Fracture Mechanisms in Rubber Toughened Poly(methyl methacrylate) and in Poly(urethane) / Poly(methyl methacrylate) Interpenetrating Polymer Networks [C] . Ph. BEGUELIN Advances in Mechanical Behaviour, Plasticity and Damage: Proceedings of EUROMAT 2000 . 2000

机译：橡胶增韧聚甲基丙烯酸甲酯和聚氨酯/聚甲基丙烯酸甲酯互穿聚合物网络中变形和断裂机理的比较
5. Multiphase biocompatible polymer blends from poly(L-lactide) and poly(methyl methacrylate). [D] . Le, Kim-Phuong Nguyen. 2006

机译：聚（L-丙交酯）和聚（甲基丙烯酸甲酯）的多相生物相容性聚合物共混物。
6. Microfluidic Fabrication of Morphology-Controlled Polymeric Microspheres of Blends of Poly(4-butyltriphenylamine) and Poly(methyl methacrylate) [O] . Saki Yoshida, Shu Kikuchi, Shinji Kanehashi, 2018

机译：聚（4-丁基三苯胺）和聚（甲基丙烯酸甲酯）共混物的形态控制聚合物微球的微流控制备
7. Fabrication of long-period gratings in poly(methyl methacrylate-co-methyl vinyl ketone-co-benzyl methacrylate)-core polymer optical fiber by use of a mercury lamp [O] . Li, Z, Tam, HY, Xu, L, 2005

机译：用汞灯制作聚甲基丙烯酸甲酯-共-甲基乙烯基酮-甲基丙烯酸苄基酯-芯聚合物光纤中的长周期光栅
8. Nuclear Magnetic Resonance Studies of Ionomers. 5. Spectra of Poly(Methyl Methacrylate-co-4-Vinyl Pyridine), Poly(Methyl Methacrylate-co-2-Methyl-5-Vinyl Pyridine), and Their Quaternized Derivatives [R] . Natansohn, A., Eisenberg, A. 1987

机译：离子聚合物的核磁共振研究。 5.聚（甲基丙烯酸甲酯 - 共-4-乙烯基吡啶甲基），聚（甲基丙烯酸甲酯 - 共聚-2-甲基-5-乙烯基吡啶）及其季铵化衍生物的光谱

Fabrication of Capillary-like Network in a Matrix of Water-soluble Polymer Using Poly(methyl methacrylate) Microfibers

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