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首页> 外文期刊>Asian Pacific Journal of Cancer Prevention >Marked Inhibition of Cellular Proliferation in the Normal Human Esophageal Epithelial Cells and Human Esophageal Squamous Cancer Cells in Culture by Carotenoids: Role for Prevention and Early Treatment of Esophageal Cancer
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Marked Inhibition of Cellular Proliferation in the Normal Human Esophageal Epithelial Cells and Human Esophageal Squamous Cancer Cells in Culture by Carotenoids: Role for Prevention and Early Treatment of Esophageal Cancer

机译：类胡萝卜素对培养的正常人食管上皮细胞和人食管鳞癌细胞中细胞增殖的明显抑制：在预防和早期治疗食管癌中的作用

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Background: Globally Esophageal cancer is a common cancer arising from human esophageal mucosal tissue.Epidemiological studies suggest inverse correlation between carotenoid intake and incident risk of this devastatingmalignancy. Methods: In an effort to examine the modulatory role of carotenoids in human esophageal carcinogenesisat a cellular level, we examined the effects of α-carotene and β-carotenes, on cell proliferation and DNA synthesis inhuman esophageal epithelial (HEE) cells and human esophageal squamous cancer (HESC) cells in in-vitro cultures.HEE and HESC cells were incubated with different concentrations of α- and β-carotenes both individually and incombination. Results: Both Carotenes significantly inhibited (p0.05) cellular proliferation and decreased DNAsynthesis in HEE and HESC cells. The effect of α- and β-carotene together on DNA synthesis in HEE and HESC cellswas significantly greater than either carotenoid alone, suggesting a synergistic effect. Greater magnitude of cellularinhibition of DNA synthesis was observed on HEE cells than HESC cells. Conclusion: Our results suggest that acombination of α-and β-carotene may provide a novel strategy for prevention and treatment of esophageal and upperaero digestive tract cancer in humans.
机译：背景：全球食管癌是人类食管粘膜组织引起的常见癌症。流行病学研究表明，类胡萝卜素的摄入与这种毁灭性恶性肿瘤的发病风险呈负相关。方法：为了在细胞水平上研究类胡萝卜素在人类食管癌变中的调节作用，我们研究了α-胡萝卜素和β-胡萝卜素对人食管上皮（HEE）细胞和人食道鳞状细胞增殖和DNA合成的影响。将HEE和HESC细胞分别与不同浓度的α-和β-胡萝卜素一起孵育。结果：两种胡萝卜素均显着抑制（p <0.05）细胞增殖，并降低HEE和HESC细胞的DNA合成。 α-和β-胡萝卜素一起对HEE和HESC细胞DNA合成的影响明显大于单独的任一类胡萝卜素，表明具有协同作用。与HESC细胞相比，在HEE细胞上观察到更大程度的DNA合成细胞抑制作用。结论：我们的结果表明，α-和β-胡萝卜素的组合可能为预防和治疗人类食道和上呼吸道消化道癌提供一种新的策略。

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