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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >CARDIOVASCULAR RISK IN PATIENTS WITH MILD TO SEVERE SUBCLINICAL HYPOTHYROIDISM
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CARDIOVASCULAR RISK IN PATIENTS WITH MILD TO SEVERE SUBCLINICAL HYPOTHYROIDISM

机译：轻度至重度亚临床甲状腺功能减退症患者的心血管风险

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Objective: Cardiovascular risk as suggested by its name refers to altered lipid profile and C-reactive protein. It is associated with hypothyroidism due to the effect of abnormal concentrations of thyroid hormones in the cardiovascular system and increased the risk of atherosclerosis. Subclinical hypothyroidism is associated with cardiac abnormalities is not well-documented. C-reactive protein one of the markers of inflammation, considered to be the predictor of cardiovascular diseases. It may be helpful in the assessment of future developments of cardiovascular abnormalities in subclinical hypothyroidism. Methods: Recently diagnosed 71 subclinical hypothyroidism patients were enrolled in the study and compared with 63 healthy individuals. Patients were divided into two groups on the basis of thyroid stimulating hormone (TSH) concentration. Thyroid profile (TSH, free thyroxine, triiodothyroinine) and C-reactive protein were estimated by enzyme-linked immunosorbent assay. Total cholesterol (TC), triglycerides (TG), and highdensity lipoprotein-cholesterol were investigated in the study population by a spectrophotometric method, and low-density lipoprotein-cholesterol (LDL-C) was measured by the Friedewald formula. Results and Conclusion: Altered lipid profile, as well as higher concentrations of C-reactive protein, was observed in subclinical hypothyroidism patients as compared to controls. Higher concentration of TC, TG, and LDL was observed in subclinical hypothyroidism patients while the concentration of high-density lipoprotein was lower in patients with subclinical hypothyroidism. The elevated concentration of C-reactive protein was also observed in the patient group. Patients having TSH >10 μIU/ml have a higher risk of developing cardiovascular disease compared to patients having TSH <10 μIU/ml and increasing concentration of C-reactive protein along with LDL-C may progress to cardiac abnormality.
机译：目的：顾名思义，心血管风险是指脂质分布和C反应蛋白改变。由于心血管系统中甲状腺激素浓度异常的影响，它与甲状腺功能低下有关，并增加了动脉粥样硬化的风险。亚临床甲状腺功能减退症与心脏异常相关，但文献记载不足。 C反应蛋白是炎症的标志之一，被认为是心血管疾病的预测因子。这可能有助于评估亚临床甲状腺功能减退症中心血管异常的未来发展。方法：将最近诊断的71名亚临床甲状腺功能减退症患者纳入研究，并与63名健康个体进行比较。根据甲状腺刺激激素（TSH）浓度将患者分为两组。通过酶联免疫吸附测定法评估甲状腺特征（TSH，游离甲状腺素，三碘甲状腺素）和C反应蛋白。通过分光光度法对研究人群中的总胆固醇（TC），甘油三酸酯（TG）和高密度脂蛋白胆固醇（LDL-C）进行了研究，并通过Friedewald公式测量了低密度脂蛋白胆固醇（LDL-C）。结果与结论：与对照组相比，亚临床甲状腺功能减退症患者的血脂变化以及C反应蛋白浓度更高。亚临床甲状腺功能减退症患者中TC，TG和LDL的浓度较高，而亚临床甲状腺功能减退症患者中高密度脂蛋白的浓度较低。在患者组中也观察到C反应蛋白的浓度升高。与TSH <10μIU/ ml的患者相比，TSH> 10μIU/ ml的患者罹患心血管疾病的风险更高，并且C反应蛋白和LDL-C的浓度增加可能会发展为心脏异常。

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