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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >ASSESSING THE BIOACTIVITY AND ANTIOXIDATIVE PROPERTIES OF SOME COMPOUNDS ISOLATED FROM ABUTILON HIRTUM (LAM.)
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ASSESSING THE BIOACTIVITY AND ANTIOXIDATIVE PROPERTIES OF SOME COMPOUNDS ISOLATED FROM ABUTILON HIRTUM (LAM.)

机译：评估从广BU香（LAM。）分离的某些化合物的生物活性和抗氧化特性

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Objectives: The present study on the methanol extract of Abutilon hirtum (Lam.) [Malvaceae] afforded ten compounds. Findings from this assessment indicated that A. hirtum leaves possessed vast potential as medicinal product especially in liver cancer treatment. Methods: Dried-powdered leaves were boiled under reflux in 10 L of petroleum ether for 8 hrs. After filtration, the solvent was evaporated; afforded 15 g of petroleum ether extract followed by boiling with reflux for 8 hrs with chloroform, then filtration and the residue was evaporated to give 34 g chloroform extract. Ethyl acetate was added and refluxed for 8 hrs, then filtration and evaporation to give 31 g ethyl acetate extract. Finally the leaves were refluxed with 10 L of 85 % aqueous MeOH, after cooling, the solution was filtered and evaporated and the residue was 210 g methanol extract then the residue was dissolved in de-ionized water (250 ml), then the salt was removed by adding excess methanol solution (2.5 L), and finally filtered. The cytotoxicity of the isolated compounds was evaluated towards HepG2 liver-carcinoma cell line using MTT assay, the antimicrobial activity was tested using the Disc agar plate method and the total antioxidant capacity was determined according to phosphomolybdenum method. Results: The isolated compounds identified as methyl gallate, cuneataside E, bergapten, gallic acid, ellagic acid, epigallocatechin-3-O-gallate, kaempferol-3-O-α-L-rhamnoside, benzyl-1-O-β-D-glucopyranoside, 2(4-hydroxyphenyl)ethyl-O-β-D-glucopyranoside and β-sitosterol. All the isolated compounds are known; but they were isolated from Abutilon hirtum for the first time. Conclusion: This report may serve as a footprint concerning the biological and pharmacological activities of A. hirtum leaves. Keywords: Abutilon hirtum, Malvaceae, HepG2, Phenolics, Antioxidant.
机译：目的：本研究从百草枯（Lam。）[锦葵科]的甲醇提取物中提供了十种化合物。该评估的结果表明，A。hirtum叶具有作为药用产品的巨大潜力，尤其是在肝癌治疗中。方法：将干粉叶子在10 L石油醚中回流煮沸8小时。过滤后，蒸发溶剂。得到15克石油醚提取物，然后与氯仿一起回流煮沸8小时，然后过滤，将残余物蒸发，得到34克氯仿提取物。加入乙酸乙酯并回流8小时，然后过滤并蒸发，得到31g乙酸乙酯提取物。最后，将叶片与10 L的85％MeOH水溶液回流，冷却后，将溶液过滤并蒸发，残余物为210 g甲醇萃取液，然后将残余物溶于去离子水（250 ml）中，然后将盐加入过量的甲醇溶液（2.5 L）除去，最后过滤。使用MTT法评估分离的化合物对HepG2肝癌细胞的细胞毒性，使用Disc琼脂平板法测试抗微生物活性，并根据磷钼法测定总抗氧化能力。结果：分离出的化合物鉴定为没食子酸甲酯，库尼他苷E，香柠檬素，没食子酸，鞣花酸，表没食子儿茶素-3-O-没食子酸酯，山ka酚-3-O-α-L-鼠李糖苷，苄基-1-O-β-D -吡喃葡萄糖苷，2（4-羟苯基）乙基-O-β-D-吡喃葡萄糖苷和β-谷甾醇。所有分离出的化合物都是已知的。但它们是第一次与Ab实分离。结论：该报告可作为有关A.hirtum叶的生物学和药理活性的足迹。关键字：util麻，锦葵科，HepG2，酚类，抗氧化剂。

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