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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >Is there treatment effect of Vinpocetine on Autonomic Dysfunction in Rats with Alzheimer
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Is there treatment effect of Vinpocetine on Autonomic Dysfunction in Rats with Alzheimer

机译：长春西汀对阿尔茨海默病大鼠自主神经功能障碍有治疗作用吗

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Alzheimer's?disease?(AD) shows less autonomic dysfunction. There was lack of?response?or prolongation of its latency in skin?sympathetic?response. Vinpocetine is a classic inhibitor of PDE1 activity. Vinpocetine treatment has been shown to enhance performance on cognitive tests in humans. The efficacy of the use of vinpocetine in clinical trials has been controversial. A comparison of multiple studies evaluating vinpocetine use in Alzheimer's?disease AD was recently conducted. Objective: Our first aim was to assess dysautonomia in?rat with Alzheimer's?disease AD electrophysiologically, using?sympathetic?skin?response?(SSR) test. The second aim in this study, evaluate of the effect of vinpocetine treatment on Alzheimer autonomic dysfunction and attention deficiency. Method: Rats were divided?into?four groups: Sham group (Group?C, i.p. saline), Alzheimer group (Group?A),?Vinpocetine group (Group V, 5mg/kg, every other day, i.p.), Alzheimer+ Vinpocetine group (Group AV). Alzheimer's?disease?was induced in old male?rats?by AlCl3 (40 mg/kg i.p.) and D-Galactose (90 mg/kg) daily for 6 weeks. Then Skin Conductance Level (SCL), which is a sympathetic skin response parameter, was measured as tonic (no-stimuli period, 2 min) and phasic SSR (simultaneously?with 15 auditory stimuli, 10 min). Tonic?SSR is useful to investigate general states of arousal and alertness, while phasic SSR is useful to study multifaceted attentional processes (related to novelty, intensity). Results: SCL was difference among groups (tonic: F=21.47, p≤0.000; phasic: F=9.86, p≤0.000). Skin conductance level (SCL) was statistically lower in Group A than Group C (p≤0.005) and Group V (p≤0.000). SCL of Group V was statistically higher then Group C (p≤0.04), Group A (p≤0.000) and Group AV (p≤0.000). SCL of Group AV was lower than Group C’s (p≤0.01). Conclusion: There were no statistically difference between Group A and Group AV. We concluded that autonomic disturbances accompanied?Alzheimer's?disease?and vinpocetine treatment couldn’t ameliorate this disturbance. Keywords: Autonomic dysfunction, Dysautonomia, Inhibitor, Skin conductance level, Sympathetic?skin?response
机译：阿尔茨海默氏病（AD）显示出较少的自主神经功能障碍。在皮肤交感反应中缺乏反应或潜伏期延长。长春西汀是PDE1活性的经典抑制剂。长春西汀治疗已显示可增强人类认知测试的表现。在临床试验中使用长春西汀的疗效一直存在争议。最近进行了多项评估长春西汀在阿尔茨海默氏病AD中使用的研究的比较。目的：我们的首要目的是通过“交感神经反应”（SSR）评估阿尔茨海默氏病AD的大鼠自主神经功能异常。这项研究的第二个目标是评估长春西汀治疗对阿尔茨海默病自主神经功能障碍和注意力不足的影响。方法：将大鼠分为四组：假手术组（C组，腹腔注射生理盐水），阿尔茨海默氏症组（A组），长春西汀组（V组，每隔一天5mg / kg，腹腔注射），阿尔茨海默+长春西汀组（AV组）。 AlCl3（40 mg / kg i.p.）和D-半乳糖（90 mg / kg）每天持续6周在老年雄性大鼠中诱发阿尔茨海默氏病。然后测量皮肤电导水平（SCL），这是一个有交感的皮肤反应参数，以补品（无刺激期，2分钟）和阶段性SSR（同时有15个听觉刺激，10分钟）测量。补品SSR可用于研究唤醒和警觉的一般状态，而阶段性SSR可用于研究多方面的注意力过程（与新颖性，强度有关）。结果：各组之间的SCL差异（张力：F = 21.47，p≤0.000;阶段：F = 9.86，p≤0.000）。 A组的皮肤电导水平（SCL）在统计学上低于C组（p≤0.005）和V组（p≤0.000）。 V组的SCL在统计学上高于C组（p≤0.04），A组（p≤0.000）和AV组（p≤0.000）。 AV组的SCL低于C组（p≤0.01）。结论：A组和AV组之间无统计学差异。我们得出的结论是，伴随“阿尔茨海默氏病”和长春西汀治疗的自主神经紊乱并不能改善这种紊乱。关键词：自主神经功能障碍，自主神经功能障碍，抑制剂，皮肤电导水平，交感皮肤反应

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