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首页> 外文期刊>Asian Journal of Pharmaceutical Sciences >Film forming systems for topical and transdermal drug delivery
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Film forming systems for topical and transdermal drug delivery

机译:用于局部和透皮给药的成膜系统

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Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system's ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier. Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance. For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance. In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.
机译:皮肤被认为是局部和全身作用的重要药物给药途径。局部治疗的有效性取决于药物的理化性质和患者对治疗方案的依从性,以及系统在治疗过程中依附于皮肤以促进药物穿过皮肤屏障渗透的能力。用于局部和皮肤病学给药的常规制剂具有某些局限性,例如对皮肤的粘附性差,通透性差和患者依从性下降。为了治疗身体组织和伤口的疾病,该药物必须在治疗部位保持有效的时间。局部用成膜系统是这样的发展中的药物递送系统,其意在局部施用到皮肤上,其粘附到身体上,形成透明的薄膜并且提供将活性成分递送到身体组织。它们旨在作为润肤剂或保护剂用于皮肤应用,以及用于全身性作用的药物的局部作用或透皮渗透。透明性是该聚合物系统的明显特征,极大地影响了患者的接受度。在当前的讨论中,成膜系统被描述为局部和透皮给药的有前途的选择。此外,还对各种类型的成膜系统(喷雾/溶液,凝胶和乳液)及其评估参数进行了评估。

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