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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >CLINICAL EVALUATION OF TRIPLE AND QUADRUPLE HELICOBACTER PYLORI ERADICATION THERAPY IN PEPTIC ULCER PATIENTS WITH DIFFERENT ABO BLOOD GROUP PHENOTYPES
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CLINICAL EVALUATION OF TRIPLE AND QUADRUPLE HELICOBACTER PYLORI ERADICATION THERAPY IN PEPTIC ULCER PATIENTS WITH DIFFERENT ABO BLOOD GROUP PHENOTYPES

机译：ABO血型不同的胃溃疡患者三联，四联幽门螺杆菌根除治疗的临床评价

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Objective: This study aimed to examine the pathological changes in gastric mucosa of Helicobacter pylori -infected peptic ulcer patients carrying different ABO phenotypes and to study the response to the 14 days’ standard triple therapy and 10 days’ quadruple therapy in peptic ulcer patients according to their ABO phenotypes. Methods: Interventional prospective randomized-controlled open-label study was performed on newly diagnosed patients with PUD. The H. pylori- positive patients were allocated into two major study groups in which they are subdivided according to ABO blood group phenotypes: Group 1 received standard H. pylori eradication triple therapy and Group 2 received standard H. pylori eradication quadruple regimen. Patients were monitored after 2 months for successful H. pylori eradication. Results: Chronic active gastritis was significantly high in patients carrying blood Group O phenotype (81.25%), while the atrophic gastritis and intestinal metaplasia were significantly high in patients carrying blood Group A phenotype (25.00% and 16.67%), respectively. 14 days’ triple therapy showed significantly lower eradication rate in H. pylori -infected peptic ulcer patients carrying blood Group O phenotype (p<0.01), meanwhile higher response was found among patients with blood Group B. 10 days’ quadruple therapy produced a significant high eradication rate in H. pylori -infected patients carrying blood Group O than those with blood Group A (p<0.01), but still both showed lower response compared to that in patients carrying blood Group B and AB phenotypes. Elderly patients showed significantly less healing efficacy than younger patients (p<0.01), and the least healing rate was noticed in female patients after both regimens. Conclusion: Lower eradication rate in H. pylori -infected was noticed in peptic ulcer patients carrying blood Group O mainly than those with other blood groups and particularly those with duodenal Ulceri. 10 days’ quadruple therapy showed significant higher eradication rate in H. pylori infection and a better ulcer healing efficacy.
机译：目的：本研究旨在探讨感染幽门螺杆菌的不同ABO表型消化性溃疡患者胃黏膜的病理变化，并根据其对14天标准三联疗法和10天四联疗法对消化性溃疡患者的反应进行研究。他们的ABO表型。方法：对新诊断的PUD患者进行干预性前瞻性随机对照开放标签研究。幽门螺杆菌阳性患者被分为两个主要研究组，根据ABO血型表型将其细分：第1组接受标准的根除幽门螺杆菌三联疗法，第2组接受标准的根除幽门螺杆菌四联疗法。 2个月后监测患者是否成功根除幽门螺杆菌。结果：携带O型血型的患者的慢性活动性胃炎显着较高（81.25％），而携带A型血型的患者的萎缩性胃炎和肠化生明显升高（分别为25.00％和16.67％）。 14天的三联疗法显示携带O型血表型的幽门螺杆菌感染的消化性溃疡患者的根除率显着降低（p <0.01），而B型血液的患者则有更高的反应。10天的四联疗法产生了显着性携带O组血液的幽门螺杆菌感染患者的根除率高于具有A组血液的患者（p <0.01），但与携带B组和AB型血液的患者相比，仍显示出较低的反应。老年患者显示出的治疗效果明显低于年轻患者（p <0.01），两种治疗方案中女性患者的治愈率最低。结论：携带O型血的消化性溃疡患者的幽门螺杆菌感染根除率要低于其他血型，尤其是十二指肠溃疡患者。 10天的四联疗法显示幽门螺杆菌感染的根除率显着提高，溃疡愈合效果更好。

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