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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >DRUG UTILIZATION PATTERN OF ANTIEPILEPTIC DRUGS: A PHARMACOEPIDEMIOLOGIC AND PHARMACOVIGILANCE STUDY IN A TERTIARY TEACHING HOSPITAL IN INDIA
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DRUG UTILIZATION PATTERN OF ANTIEPILEPTIC DRUGS: A PHARMACOEPIDEMIOLOGIC AND PHARMACOVIGILANCE STUDY IN A TERTIARY TEACHING HOSPITAL IN INDIA

机译：抗菌药物的药物利用模式：印度第三级医院的药物流行病学和药敏性研究

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Objective: Epilepsy is the second most common chronic neurological condition seen by neurologists. It is estimated that there are 55, 00,000 persons with epilepsy in India. So, the present study aims at getting an insight into the type of epileptic seizures prevalent in a tertiary referral teaching Hospital in eastern India, to describe the drug utilization pattern of antiepileptic drugs (AEDs) for the management of various forms of epileptic seizures over a period of one year and to investigate the pattern and extent of adverse drug reactions (ADRs) with AEDs. Methods: Data from five hundred twenty eight patients with epilepsy at the outpatient of Neurology Department, SCB Medical College and Hospital, Cuttack was collected according to detailed semi-structured questionnaire. The data includes demographic data, AEDs data and ADR data. Results and Discussion: Tonic clonic seizures were most prominent followed by complex partial seizures. Most of patients are young and epileptic seizures are more common in man. 47% of cases are refractory. Polytherpy was most frequently used in all type of epileptic seizures. Sodium Valproate was the most frequently prescribed AED followed by Phenytion sodium and Carbamazepine. The drugs prescribed are mainly from the Essential drug list. The ADRs are found to mild and predominant in female. Conclusion: This study strongly highlights the need for therapeutic drug monitoring of epileptic patients. Measures should be taken to improve rational use of antiepileptic drugs to minimise the number of refractory cases of epilepsy. There is under utilization of newer AEDs. Inclusion of newer AEDs like Lamotrigine, Topiramate etc in the Essential Drug List is recommended. Female patients need special attention during medication
机译：目的：癫痫是神经科医生所见的第二大最常见的慢性神经系统疾病。据估计，印度有55，00,000的癫痫患者。因此，本研究旨在深入了解印度东部三级转诊教学医院中流行的癫痫发作的类型，以描述抗癫痫药（AED）的药物利用模式，以管理超过30％的各种形式的癫痫发作。为期一年，并调查与AED发生药物不良反应（ADR）的方式和程度。方法：根据详细的半结构化问卷，收集来自库塔克SCB医学院和医院神经内科门诊的528例癫痫患者的数据。该数据包括人口统计数据，AED数据和ADR数据。结果与讨论：强直性阵挛性癫痫发作最为明显，其次是复杂的部分性癫痫发作。大多数患者是年轻患者，癫痫发作在男性中更为常见。 47％的病例为难治性病例。 Polytherpy最常用于所有类型的癫痫发作中。丙戊酸钠是最常用的AED，其次是苯妥英钠和卡马西平。处方药主要来自基本药物清单。发现ADR在女性中轻度居多。结论：本研究强烈强调了对癫痫患者进行治疗药物监测的必要性。应采取措施改善抗癫痫药物的合理使用，以最大程度地减少难治性癫痫病例的数量。目前正在使用较新的AED。建议在基本药物清单中包括较新的AED，如Lamotrigine，Topiramate等。女性患者在服药期间需要特别注意

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