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首页> 外文期刊>Annals of Indian Academy of Neurology >Factors predicting poor outcome in patients with fulminant Guillaine-Barré syndrome
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Factors predicting poor outcome in patients with fulminant Guillaine-Barré syndrome

机译：暴发性吉兰-巴雷综合征患者预后不良的因素

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摘要

This paper describes three patients with acute fulminant Guillain-Barrι Syndrome (GBS) with electrophysiologically inexcitable peripheral nerves not responding to two courses of intravenous immunoglobulin. Their clinical profile is compared with two other GBS patients having similar severity of disease but with demyelinative features, managed similarly during the same period. Patients who failed to respond were elderly with a mean age of 60 years, had prodromal diarrhea, rapid progression of muscle weakness requiring mechanical ventilation within 24 hours, dense weakness of all four limbs with cardiovascular autonomic symptoms and inexcitable peripheral nerves. The remaining two who recovered well were relatively younger with a mean age of 50 years, had no prodromal diarrhea, required ventilatory support by fourth day of illness, no cardiovascular autonomic symptoms and demyelinative neuropathy.
机译：本文描述了三例急性暴发性格林-巴利综合征（GBS），其电生理学上无法激发的周围神经对两个疗程的静脉免疫球蛋白无反应。将他们的临床特征与其他两名具有相似疾病严重程度但具有脱髓鞘特征的GBS患者进行比较，并在同一时期进行相似的治疗。未能反应的患者是平均年龄为60岁的老年人，前驱性腹泻，肌肉无力快速发展，需要在24小时内进行机械通气，具有心血管自主症状的所有四个肢体密集无力和周围神经兴奋。其余两个恢复良好的人相对年轻，平均年龄为50岁，没有前驱性腹泻，在疾病第四天之前需要通气支持，没有心血管自主神经症状和脱髓鞘性神经病。

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