...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Arquivo Brasileiro de Medicina Veterinaria e Zootecnia >Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
【24h】

Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

机译：长春新碱化学疗法治疗犬可传播性病的犬的生活质量评分的临床应用

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.
机译：在这项前瞻性研究中，使用93只荷瘤犬对犬进行长春新碱化疗的犬的长春新碱化疗期间的生活质量评分的临床实用性进行了调查。诊断时，根据修改后的适用于狗的卡诺夫斯基评分（CKS）评估临床数据和性能状态。每周间隔用硫酸长春新碱（0.025mg / kg）治疗动物，直到肿瘤从宏观上消失为止。记录直到第一次不良事件和死亡的时间。在一项试点研究中，CKS显示出观察者之间的一致性很高（kappa = 0.735;加权kappa = 0.835）。 CKS允许详细监测治疗期间的不良反应。 Cox回归显示，低绩效评分和减轻体重是化疗期间死亡的独立预测因素。改良的Karnofsky性能评分是一种简单且可重复的临床工具，能够在CTVT治疗后评估患者预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号