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首页> 外文期刊>Animal Reproduction Science >Vincristine and ivermectin combination chemotherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospective outcome evaluation
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Vincristine and ivermectin combination chemotherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospective outcome evaluation

机译：Vincristine和Ivermectin组合化疗在狗的自然传播性失真肿瘤不同的细胞形态模式：潜在的结果评估

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摘要

Vincristine is the first-line drug for the chemotherapy of canine transmissible venereal tumor (CTVT). Drug resistance is related to tumor cyto-morphological patterns of CTVT. There are anticancer properties of ivermectin, thus, a combination of ivermectin and vincristine could be an effective chemo-therapeutic treatment regimen for CTVT. Study aims, therefore, were to (1) assess the frequency of CTVT cyto-morphologies, and (2) evaluate treatment efficacy and possible adverse reactions to vincristine compared with a combination vincristine and ivermectin. Dogs (n = 41) with CTVT were characterized by tumor cyto-morphology and disease severity and of those, 20 were randomly allocated into two groups. There was a control group (G-Vin; n = 10) in which there was treatment with vincristine; and an experimental group (G-Iv/Vin; n = 10) in which there was treatment with the ivermectin/vincristine combination. Although dogs in the G-Iv/Vin group had more severe disease at the beginning of the study (P = 0.0031), the number of weeks and chemotherapy sessions until tumor remission were similar among dogs of the two groups, indicating both treatments were effective. There was a decrease in the leukocyte counts (P = 0.0020), related to neutropenia (P = 0.0371) in the G-Vin but not the G-Iv/Vin treatment group. There was no tumor resistance that developed during the study regardless of the treatment regimen used or tumor cytomorphology. In summary, the use of the vincristine/ivermectin combination was well tolerated and efficacious for CTVT treatment.
机译：血管酮是犬传播性失血肿瘤（CTVT）化疗的一线药物。耐药性与CTVT的肿瘤细胞形态模式有关。伊维菌素存在抗癌性质，因此，Ivermectin和血管内的组合可以是CTVT的有效化学治疗治疗方案。因此，研究目标是（1）评估CTVT细胞形态的频率，（2）与组合中文组合和Ivermectin相比，评估对血管内的治疗疗效和可能的不良反应。具有CTVT的狗（n = 41）的特征是肿瘤细胞形态和疾病严重程度，并且将20个随机分配成两组。有一种对照组（G-VIN; n = 10），其中有血管内治疗;和实验组（G-IV / VIN; n = 10），其中用伊维菌素/长春杂菌素组合治疗。虽然G-IV / VIN组中的狗在研究开始时具有更严重的疾病（p = 0.0031），但在两组狗的狗中肿瘤缓解直到肿瘤缓解的数周和化疗，表明这两种治疗都是有效的。白细胞计数（p = 0.0020）减少，与G-Vin中的中性粒细胞纤维（p = 0.0371）相关，但不是G-IV / vin处理组。无论使用的治疗方案或肿瘤细胞形态，都没有在研究中开发的肿瘤抗性。总之，使用血管素/伊维菌素组合的使用对于CTVT处理是良好的耐受性和有效的。

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