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Introducing Polyautoimmunity: Secondary Autoimmune Diseases No Longer Exist

机译：引入多自身免疫：不再存在继发性自身免疫疾病

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Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjögren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006–September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.
机译：自身免疫性疾病中类似的病理生理机制刺激了对共同遗传根源的搜索。多自身免疫定义为单个患者中存在一种以上的自身免疫疾病。当三种或更多种自身免疫性疾病共存时，这种情况称为多发性自身免疫综合症（MAS）。我们分析了属于四个自身免疫性疾病队列的1,083例患者的多自身免疫性。在373例患者中观察到了多自身免疫（34.4％）。自身免疫性甲状腺疾病（AITD）和干燥综合征（SS）是最常见的疾病。与多自身免疫显着相关的因素是女性和家族性自身免疫。通过系统的文献回顾，对所有MAS病例进行了更新搜索（2006年1月至2011年9月）。检索到142篇文章，对应226例。接下来，我们进行了聚类分析，其中AITD其次是系统性红斑狼疮和SS是遇到的最分层的疾病。我们的结果表明，自身免疫性疾病并存并不罕见，并且遵循分组模式。多自体免疫是针对这种疾病关联提出的术语，其中包括这些疾病的共同起源的概念。

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