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How Does Age at Onset Influence the Outcome of Autoimmune Diseases?

机译:发病年龄如何影响自身免疫疾病的结果?

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The age at onset refers to the time period at which an individual experiences the first symptoms of a disease. In autoimmune diseases (ADs), these symptoms can be subtle but are very relevant for diagnosis. They can appear during childhood, adulthood or late in life and may vary depending on the age at onset. Variables like mortality and morbidity and the role of genes will be reviewed with a focus on the major autoimmune disorders, namely, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes mellitus (T1D), Sjögren's syndrome, and autoimmune thyroiditis (AITD). Early age at onset is a worst prognostic factor for some ADs (i.e., SLE and T1D), while for others it does not have a significant influence on the course of disease (i.e., SS) or no unanimous consensus exists (i.e., RA and MS).
机译:发病年龄是指个体经历疾病的最初症状的时间段。在自身免疫性疾病(ADs)中,这些症状可能很微妙,但与诊断非常相关。它们可以出现在儿童期,成年期或生命晚期,并且可能会因发病年龄而异。诸如死亡率和发病率以及基因的作用等变量将以主要的自身免疫性疾病为重点,即系统性红斑狼疮(SLE),类风湿性关节炎(RA),多发性硬化症(MS),1型糖尿病(T1D) ,干燥综合征和自身免疫性甲状腺炎(AITD)。对于某些AD(如SLE和T1D),发病年龄的早发是最糟糕的预后因素,而对于另一些AD,它对疾病进程(即SS)没有显着影响,或者没有一致的共识(即RA和RA)。多发性硬化症)。

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