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首页> 外文期刊>Arquivos de Gastroenterologia >Utiliza??o da cromoendoscopia com azul de toluidina mais solu??o de Lugol para diagnóstico precoce de les?es pré-malignas esofágicas e neoplasias superficiais em pacientes de alto risco
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Utiliza??o da cromoendoscopia com azul de toluidina mais solu??o de Lugol para diagnóstico precoce de les?es pré-malignas esofágicas e neoplasias superficiais em pacientes de alto risco

机译：甲苯胺蓝加Lugol溶液在彩色内窥镜检查中对高危患者食道癌前病变和浅表肿瘤的早期诊断

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BACKGROUND: Esophageal cancer is the eighth most common cancer. The prognosis is bleak in patients with advanced stages. Patients with early disease have a better prognosis than those with advanced stage. There are several techniques for the screening of premalignant and superficial lesions including chromoendoscopy. OBJECTIVE: This article aimed to determine the effectiveness of chromoendoscopy with toluidine blue combined with Lugol’s solution for diagnosis of esophageal premalignant and superficial neoplastic lesions in high risk patients. METHODS: Routine white light upper endoscopy was performed. Toluidine blue was sprayed from the gastroesophageal junction to 20 cm of the dental arch. Then the uptake dye areas were characterized. Later Lugol’s solution was sprayed. Areas with less-intense staining were characterized. Biopsy of the toluidine blue capturing areas and areas with less-intense staining of Lugol’s solution were taken. In the cases where lesions were not evidenced after application of dyes, biopsies four quadrants of the esophageal mucosa were taken. The samples were evaluated by a digestive pathologist. RESULTS: Barrett’s esophagus was the most common premalignant lesion and the early neoplastic lesion was adenocarcinoma with a sensitivity of 100%, specificity 85.7%, positive predictive value 30%, negative predictive value 100%, positive likelihood ratio 7 negative likelihood ratio 0. CONCLUSION: Chromoendoscopy with toluidine blue combined with Lugol’s solution is a useful tool in the screening of esophageal premalignant lesions and superficial neoplasms.
机译：背景：食道癌是第八大最常见的癌症。晚期患者的预后暗淡。早期疾病患者比晚期患者预后更好。有几种用于筛查恶变前和浅表病变的技术，包括色内镜检查。目的：本文旨在确定甲苯胺蓝结合Lugol溶液对胃镜检查在高危患者食管癌前和浅表肿瘤病变中的诊断作用。方法：常规白光上镜检查。从胃食管连接处喷洒甲苯胺蓝至20 cm的牙弓。然后表征摄取染料区域。后来，卢戈尔的溶液被喷洒了。对染色强度较低的区域进行了表征。对甲苯胺蓝捕获区域和对Lugol溶液染色较弱的区域进行活检。在使用染料后未发现病变的情况下，进行活检，检查食管粘膜的四个象限。样品由消化病理学家评估。结果：Barrett食管是最常见的癌前病变，早期肿瘤病变是腺癌，敏感性为100％，特异性为85.7％，阳性预测值为30％，阴性预测值为100％，阳性似然比为7，阴性似然比为0。结论：用甲苯胺蓝结合卢戈尔溶液的内窥镜检查是筛选食道癌前病变和浅表肿瘤的有用工具。

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