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首页> 外文期刊>IBRO Reports >Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice
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Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice

机译：C57黑色老龄小鼠对海马点燃性癫痫发作的敏感性增加

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Graphical abstract Display Omitted Highlights ? Hippocampal kindling by daily stimulation conducted in aging and young mice. ? Stimulation parameters were comparable in the two groups of mice. ? No significant age difference in cumulative afterdischarges to stage 3–5 seizures. ? Longer afterdischarges and faster seizure progression observed in the aging mice. ? Aging mice may have increased susceptibility to hippocampal kindling seizures. Abstract The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence of the above pathologies remains unclear. We used classic kindling to explore this issue as the kindling model is highly reproducible and allows close monitoring of electrographic and motor seizure activities in individual animals. We kindled male young and aging mice (C57BL/6 strain, 2–3 and 18–22 months of age) via daily hippocampal CA3 stimulation and monitored seizure activity via video and electroencephalographic recordings. The aging mice needed fewer stimuli to evoke stage-5 motor seizures and exhibited longer hippocampal afterdischarges and more frequent hippocampal spikes relative to the young mice, but afterdischarge thresholds and cumulative afterdischarge durations to stage 5 motor seizures were not different between the two age groups. While hippocampal injury and structural alterations at cellular and micro-circuitry levels remain to be examined in the kindled mice, our present observations suggest that susceptibility to hippocampal CA3 kindling seizures is increased with aging in male C57 black mice.
机译：图形摘要显示省略的突出显示？在衰老和年幼的小鼠中通过每日刺激进行海马点燃。 ？两组小鼠的刺激参数相当。 ？在3-5期癫痫发作的累积出院后，年龄没有显着差异。 ？在衰老的小鼠中观察到更长的后放电和更快的癫痫发作进程。 ？衰老的小鼠对海马点燃性癫痫发作的敏感性可能增加。摘要癫痫的发病率随着年龄的增长而增加。中风，痴呆和脑瘤是公认的老年人群新发癫痫发作的危险因素，并且这些疾病的发生率也随着年龄的增长而增加。在没有上述病理的情况下，衰老是否与较高的癫痫发作敏感性有关。我们使用经典的点燃方法来探索这个问题，因为点燃模型具有很高的可重复性，并且可以密切监视个别动物的电子照相和运动性癫痫发作活动。我们通过每日海马CA3刺激点燃了雄性年轻和衰老的小鼠（C57BL / 6株，年龄在2–3和18–22个月），并通过视频和脑电图记录监测了癫痫发作的活动。与年轻小鼠相比，衰老的小鼠需要较少的刺激才能诱发5期运动性癫痫发作，并且表现出更长的海马后放电和更频繁的海马突波发作，但是两个年龄组之间的后放电阈值和第5期运动性癫痫发作的累积后放电持续时间没有差异。虽然在点燃的小鼠中海马损伤以及细胞和微电路水平的结构改变仍有待检查，但我们目前的观察结果表明，随着年龄的增长，雄性C57黑小鼠对海马CA3点燃癫痫的敏感性增加。

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