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首页> 外文期刊>IBRO Reports >A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices
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A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices

机译：甘露醇和苯妥英钠对成年大鼠新皮层切片的抗惊厥作用和作用机制的比较

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Highlights ? In cortical slices addition of 30mM Mannitol is anticonvulsant. ? Mannitol decreases the rate of epileptiform discharges. ? As an anticonvulsant Mannitol is as effective as Phenytoin. ? Mannitol is already used routinely in neurointensive care. ? Mannitol might be used in neurointensive care also as an anticonvulsant. Abstract We show that, in adult rat neocortical slices, an anticonvulsant effect comparable to that of Phenytoin can be obtained through a Mannitol-induced increase in extracellular osmolarity of only 30mOsm/L. The anticonvulsant action of extracellular hyperosmolarity has been known for decades but has not found a feasible therapeutic application, yet. A 30mOsm/L increase in extracellular osmolarity is already utilized in neurocritical care though not as an anticonvulsant agent: the data suggest a possible effective anticonvulsant use, too, in this setting. We used multiple electrode arrays to characterize and compare the anticonvulsant mechanisms of Mannitol and Phenytoin. Phenytoin decreased the voltage, duration and spatial spread of rhythmic repetitive, ictal-like activity. In contrast, Mannitol did not significantly affect voltage, duration and spatial spread of rhythmic repetitive, ictal-like activity but rather it inhibited the rate of epileptiform discharges.
机译：强调 ？在皮层中添加30mM甘露醇是抗惊厥药。 ？甘露醇降低癫痫样放电的速率。 ？甘露醇作为抗惊厥药与苯妥英钠一样有效。 ？甘露醇已被常规用于神经重症监护。 ？甘露醇也可用作抗惊厥药，用于神经重症监护。摘要我们显示，在成年大鼠新皮质切片中，通过甘露醇诱导的细胞外渗透压升高仅30mOsm / L，可以获得与苯妥英钠相当的抗惊厥作用。细胞外渗透压的抗惊厥作用已经有数十年的历史了，但尚未发现可行的治疗应用。尽管未将其用作抗惊厥药，但神经重症监护已将细胞外渗透压提高30mOsm / L，尽管该数据还表明在这种情况下也可能有效使用抗惊厥药。我们使用多个电极阵列来表征和比较甘露醇和苯妥英的抗惊厥机制。苯妥英钠可降低节律性重复性，发作性活动的电压，持续时间和空间分布。相比之下，甘露醇并没有显着影响节律性重复，发作样活动的电压，持续时间和空间分布，但它抑制了癫痫样放电的速率。

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