• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>IBRO Reports >Long-term caffeine intake exaggerates PTSD-like symptoms independent of HPA axis activity
【24h】

Long-term caffeine intake exaggerates PTSD-like symptoms independent of HPA axis activity

机译：长期摄入咖啡因会增加PTSD样症状，与HPA轴活动无关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Based on our results, we can speculate that NCX1, by regulating microglia/astrocytes activation and polarization, might inter- fere with the neurogenic potential of astrocytes under ischemic conditions. During our daily life, we face stressful events to which our body generates responses and memories of these events are stored in order to cope with their future occurrence. Transducer of ErbB2 (Tob), a member of the Tob/BTG anti-proliferative family proteins, has been implicated in cell proliferation, differentiation and the DNA damage response. In the brain, there are reports suggesting that Tob regulates complex behavioral processes such as learning and memory. Interestingly, Tob knockout mice exhibited increased brain weights in conjunction with structural magnetic resonance imaging (MRI) which revealed increased volume compared to wild- type mice. Behavior analyses showed increased levels of anxiety and fear expression in Tob knockout mice. Additionally, fMRI anal- ysis for the functional connectivity between different brain parts in Tob-knockout mice revealed altered hippocampal and pre-frontal cortex connectivity, which might predispose for impaired stress handling in mice. Since Tob protein has been shown to be respon- sive to different stress stimuli, restraint stress for mice subjects has been utilized as a stress model in this study. The neuronal molecular pathway for Tob in response to stress involving dynamic phosphorylation signaling events and changes in neurotransmit- ter’s postsynaptic receptor levels will be elucidated. This study sets the stage for investigating the potential function of Tob in the brain in response to stress and involvement in neurological disorders.
机译：根据我们的结果，我们可以推测，NCX1通过调节小胶质细胞/星形胶质细胞的活化和极化作用，可能会干扰缺血条件下星形胶质细胞的神经发生潜能。在日常生活中，我们面对压力大的事件，我们的身体会对此作出反应，并存储这些事件的记忆，以应对将来的事件。 Tob / BTG抗增殖家族蛋白的成员ErbB2（Tob）的转导子与细胞增殖，分化和DNA损伤反应有关。在大脑中，有报道表明Tob可以调节复杂的行为过程，例如学习和记忆。有趣的是，与野生型小鼠相比，Tob基因敲除小鼠与结构磁共振成像（MRI）一起显示出增加的脑重量。行为分析显示，Tob基因敲除小鼠的焦虑和恐惧表达水平增加。此外，功能磁共振成像分析对Tob基因敲除小鼠的不同大脑部分之间的功能连接性进行了分析，结果表明海马和前额叶皮层的连接性发生了变化，这可能导致小鼠的压力处理能力降低。由于已显示Tob蛋白对不同的应激刺激有反应，因此在这项研究中将对小鼠受试者的约束应激用作应激模型。阐明了Tob响应涉及动态磷酸化信号事件和神经递质突触后受体水平变化的应激的神经元分子途径。这项研究为研究Tob在应对压力和参与神经系统疾病时在大脑中的潜在功能奠定了基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号