• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>IBRO Reports >Systemic human umbilical cord-derived mesenchymal stem cells administration restore abnormal behaviors in schizophrenia animal model
【24h】

Systemic human umbilical cord-derived mesenchymal stem cells administration restore abnormal behaviors in schizophrenia animal model

机译：全身性人脐带间充质干细胞给药可恢复精神分裂症动物模型的异常行为

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Amyloid precursor protein regulates depolarization-induced calcium-mediated signaling in brain slices Systemic human umbilical cord-derived mesenchymal stem cells administration restore abnormal behaviors in schizophrenia animal model To date, the therapeutic option of schizophrenia has been limited to monoamine-based antipsychotic drugs, and currently available drugs have not covered heterogeneous schizophrenia patients and often have serious adverse side effects. Based on the genome wide association study (GWAS) indicating close relationship on the role of immune system in schizophrenia, we conducted a proof of concept study on umbilical cord- derived mesenchymal stem cell (UC-MSC) application, which has immune-modulatory function, in schizophrenia animal models. Schizophrenia-relevant behaviors (disruption of latent inhibi- tion, social deficit, depressive-like behaviors) were induced by amphetamine administration regimen in mice (amphetamine- sensitized mice) and the effect of single intravenous administration of human UC-MSC was examined. As a result, amphetamine- sensitized mice showed neuroinflammatory reaction in the striatum and hippocampus and a persistent TNF-a elevation in serum and lymph node after amphetamine withdrawal. UC-MSC.
机译：淀粉样蛋白前体蛋白调节脑切片中去极化诱导的钙介导的信号传导全身性人脐带来源的间充质干细胞给药可恢复精神分裂症动物模型的异常行为迄今为止，精神分裂症的治疗选择仅限于单胺类抗精神病药，并且当前可用的药物尚未涵盖异质性精神分裂症患者，并且经常具有严重的不良副作用。基于表明免疫系统在精神分裂症中作用密切相关的全基因组关联研究（GWAS），我们对脐带衍生的间充质干细胞（UC-MSC）应用进行了概念验证研究，该应用具有免疫调节功能，在精神分裂症动物模型中。苯丙胺给药方案在小鼠（苯丙胺敏化的小鼠）中诱导了精神分裂症相关行为（潜在抑制的破坏，社会缺陷，抑郁样行为），并检查了单次静脉内施用人UC-MSC的效果。结果，苯丙胺致敏的小鼠在苯丙胺戒断后在纹状体和海马中显示出神经炎症反应，并且血清和淋巴结中的TNF-α持续升高。 UC-MSC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号