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首页> 外文期刊>Ibnosina Journal of Medicine and Biomedical Sciences >Homocysteine and hematological indices in hemodialysis patients
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Homocysteine and hematological indices in hemodialysis patients

机译：血液透析患者的同型半胱氨酸和血液学指标

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Objectives: To explore the relationship between homocysteine and various hematological indices in hemodialysis patients. Patients and Methods: This case-control study comprised 60 hemodialysis patients and 60 healthy controls matched for gender and age. Hemodialysis duration was 3.2±2.9 year at frequency of 2.6±0.6/week. Hypertension and diabetes were the most common self-reported disorders among the hemodialysis patients. Results: Serum homocysteine was significantly higher in hemodialysis patients than in controls (50.8±9.7 vs. 13.1±3.7 μmol/l, P=0.000). White blood cell (WBC) and platelet (PLT) counts were significantly higher in hemodialysis patients than in controls [(7.18±2.37 x109/L and 266.3±111.9 x109/L vs 5.95±1.37 x109/L and 222.0±54.1 x109/L) with P=0.017 and P=0.045, respectively]. In contrast, red blood cell (RBC), hemoglobin, and hematocrit were significantly lower in hemodialysis patients (3.1±0.5 x1012/L, 8.9±1.5 gm/dl and 26.3±4.6%) than in controls (4.0±0.4 x1012/L, 12.8±1.6 gm/dl and 45.0±4.6%) with P=0.000. Prothrombin time (PT) and international normalized ratio (INR) were significantly higher in hemodialysis patients compared to controls (16±3 sec and 1±0 vs. 14±0 sec and 1.0±0.1, P=0.000), whereas activated partial thromboplastin time (APTT) was significantly decreased in hemodialysis patients (25±5 vs 33±2 sec, P=0.000). Homocysteine correlated directly with WBC count (r=0.338, P=0.008) and PLT count (r=0.369, P=0.000) whereas inverse correlations were found between homocysteine and RBC count (r=- 0.648, P=0.000), hemoglobin (r=-0.733, P=0.000) and hematocrit (r=-0.836, P=0.000). In addition, homocysteine showed direct correlations with PT (r=0.564, P=0.000) and INR (r=0.657, P=0.000) and inverse correlation with APTT (r=-0.690, P=0.000). Conclusion: Serum homocysteine was significantly higher in hemodialysis patients compared to controls. Homocysteine correlated directly with WBC count, PLT count, PT and INR, and inversely with RBC count, hemoglobin, hematocrit and APTT.
机译：目的：探讨血液透析患者同型半胱氨酸与血液学指标之间的关系。患者和方法：该病例对照研究包括60例血液透析患者和60例性别和年龄相匹配的健康对照。血液透析持续时间为3.2±2.9年，频率为2.6±0.6 /周。高血压和糖尿病是血液透析患者中​​最常见的自我报告的疾病。结果：血液透析患者的血清高半胱氨酸水平显着高于对照组（50.8±9.7 vs. 13.1±3.7μmol/ l，P = 0.000）。血液透析患者的白细胞（WBC）和血小板（PLT）计数显着高于对照组[（（7.18±2.37 x109 / L和266.3±111.9 x109 / L，而5.95±1.37 x109 / L和222.0±54.1 x109 / L ），分别为P = 0.017和P = 0.045]。相比之下，血液透析患者（3.1±0.5 x1012 / L，8.9±1.5 gm / dl和26.3±4.6％）的红细胞（RBC），血红蛋白和血细胞比容显着低于对照组（4.0±0.4 x1012 / L） （12.8±1.6 gm / dl和45.0±4.6％），P = 0.000。与对照组相比，血液透析患者的凝血酶原时间（PT）和国际标准化比率（INR）显着更高（16±3秒和1±0比14±0秒和1.0±0.1，P = 0.000），而活化部分凝血活酶血液透析患者的时间（APTT）显着减少（25±5 vs 33±2 sec，P = 0.000）。同型半胱氨酸与WBC计数（r = 0.338，P = 0.008）和PLT计数（r = 0.369，P = 0.000）直接相关，而同型半胱氨酸与RBC计数（r =-0.648，P = 0.000），血红蛋白（ r = -0.733，P = 0.000）和血细胞比容（r = -0.836，P = 0.000）。此外，同型半胱氨酸与PT（r = 0.564，P = 0.000）和INR（r = 0.657，P = 0.000）呈正相关，与APTT呈负相关（r = -0.690，P = 0.000）。结论：血液透析患者的血清同型半胱氨酸水平明显高于对照组。同型半胱氨酸与WBC计数，PLT计数，PT和INR直接相关，与RBC计数，血红蛋白，血细胞比容和APTT呈负相关。

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