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首页> 外文期刊>Immunity Ageing >Understanding ageing: Biomedical and bioengineering approaches, the immunologic view
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Understanding ageing: Biomedical and bioengineering approaches, the immunologic view

机译：了解老龄化：生物医学和生物工程学方法，免疫学观点

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During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a steady decline in birth rates in all developed countries, has led to an unprecedented demographic revolution characterized by an explosive growth in the number and proportion of older people. Ageing is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed Immunosenescence: some immunological parameters are commonly notably reduced in the elderly and, reciprocally good function is tightly correlated to health status. Hence, a better understanding of Immunosenescence and the development of new strategies to counteract it are essential for improving the quality of life of the elderly population.
机译：在过去的一个世纪中，人类的平均预期寿命比过去的10,000年更长。我们现在生活在一个快速老化的世界中。预期寿命的急剧上升，加上所有发达国家出生率的持续下降，导致了前所未有的人口革命，其特征是老年人的数量和比例呈爆炸性增长。衰老是一个复杂的过程，会对免疫系统的发育及其功能产生负面影响。 T和B细胞系统在整个生命周期中的逐渐变化对免疫应答的反应能力产生重大影响。免疫能力的这些与年龄相关的累积变化被称为免疫衰老：老年人中一些免疫学参数通常显着降低，而良好的功能则与健康状况密切相关。因此，对免疫衰老有更好的了解，并开发出新的对策，以改善老年人的生活质量。

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