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Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains

机译：依布硒仑和N-乙酰半胱氨酸对人原代成纤维细胞株复制衰老的影响

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Administration of selected concentrations of ebselen and N-acetyl cysteine have been proven to display an antioxidant potential based on their effect on markers of T cell integrity and function in human peripheral blood mononuclear cells and CD4 + T cell clones. Here we assessed the impact of various antioxidant concentrations on replicative aging of primary human fibroblast strains derived from embryonic lung (MRC-5) and foreskin (HFF). None of the antioxidant concentrations affected the cumulative population doublings, levels of oxidative DNA damage, intracellular GSH:GSSG ratio, potency of heat shock responses and the induction of senescence in both fibroblast strains. Our results showed no effect of both antioxidants on primary fibroblast strains and reveal their cell type specific antioxidant potential.
机译：基于选择的依瑟硒仑和N-乙酰基半胱氨酸对人外周血单核细胞和CD4 + T细胞克隆中T细胞完整性和功能标记的作用，已证明其具有抗氧化作用。在这里，我们评估了各种抗氧化剂浓度对源自胚胎肺（MRC-5）和包皮（HFF）的原代人成纤维细胞株复制性衰老的影响。两种成纤维细胞菌株中，抗氧化剂的浓度均不影响累积种群倍增，氧化DNA损伤水平，细胞内GSH：GSSG比，热休克反应的效力和衰老的诱导。我们的结果表明两种抗氧化剂对原代成纤维细胞株均无影响，并揭示了它们的细胞类型特异性抗氧化剂潜力。

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