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首页> 外文期刊>Immunity Ageing >NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study
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NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study

机译：TAMRISK研究显示，含有3个（NLRP3）炎性小体基因多态性rs7512998（C> T）的NLR家族吡啶结构域可预测与年龄相关的血压升高

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Background The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes have also been implicated in the initiation or progression of metabolic disorders such as atherosclerosis, type 2 diabetes and obesity. The association of NLRP3 genetic variant rs7512998 with blood pressure and hypertension was studied in a 50-year-old Finnish cohort with a subpopulation who had available data on blood pressure measurements also at the age of 45 years. Results NLRP3 gene polymorphism rs7512998 C-allele was associated with higher systolic (p?=?0.006) and diastolic (p?=?0.011) blood pressure compared to the TT-genotype carriers in 50-year-old subjects. In addition, by analysis of variance for repeated measures between ages of 45- and 50 years there was a significant time by genotype interaction; blood pressure increased more in subjects with the C-allele both in systolic (p?=?0.035) and diastolic (p?=?0.012) values. However, no association with diagnosed hypertension was found. Conclusion We report for the first time that NLRP3 gene polymorphism rs7512998 was associated with systolic and diastolic blood pressure in 50-year-old subjects. In addition, an effect of this variation upon blood pressure was seen in these same subjects in a 5-year follow-up from a 45-year-old cohort to 50 years of age.
机译：背景技术通过细胞应激激活包含3（NLRP3）炎性小体的NLR家族吡喃结构域会导致炎性小体的激活，并且NLRP3基因多态性与自身炎症性疾病有关。炎症小体还与代谢紊乱的发生或发展有关，例如动脉粥样硬化，2型糖尿病和肥胖症。在一个50岁的芬兰人群中研究了NLRP3基因变异rs7512998与血压和高血压的关系，该人群具有同样在45岁时可获得血压测量数据的亚人群。结果与50岁的TT基因型携带者相比，NLRP3基因多态性rs7512998 C等位基因与较高的收缩压（p？=？0.006）和舒张压（p？=？0.011）相关。另外，通过对45岁至50岁之间重复测量的方差分析，基因型相互作用显着缩短了时间。带有C等位基因的受试者的收缩压（p？=？0.035）和舒张压（p？=？0.012）值的血压升高幅度更大。但是，未发现与确诊的高血压相关。结论我们首次报道NLRP3基因多态性rs7512998与50岁受试者的收缩压和舒张压有关。另外，在这些相同的受试者中，从45岁到50岁的人群进行了5年的随访，观察到了这种变化对血压的影响。

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