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首页> 外文学位 >Association of the PAI-1 4G/5G polymorphism with blood pressure in the Quebec Family Study: Interactions with adiposity, physical activity, and the ACE I/D polymorphism.
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Association of the PAI-1 4G/5G polymorphism with blood pressure in the Quebec Family Study: Interactions with adiposity, physical activity, and the ACE I/D polymorphism.

机译：魁北克家庭研究中PAI-1 4G / 5G多态性与血压的关联：与肥胖，身体活动和ACE I / D多态性的相互作用。

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摘要

Background. Blood pressure (BP) is associated with increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) and angiotensin converting enzyme (ACE). ACE and its insertion/deletion (I/D) polymorphism have been well studied for their association with BP. However, the role of the PAI-1 4G/5G polymorphism in the association between PAI-1 and BP is less clear. Furthermore, factors such as adiposity, physical activity (PA), and other genes may influence BP. Thus the aims of this study were to examine the association of the 4G/5G polymorphism with BP, and its interactions with adiposity, physical activity, and the ACE I/D polymorphism on BP.;Methods. Eight hundred and fifteen subjects from the Quebec Family Study with valid data for height, weight, body mass index (BMI); percent fat; PA levels; systolic, diastolic and mean arterial BP (SBP, DBP, MAP); and genotype were analyzed.;Results. PAI-1 4G/5G genotype was not associated with any BP variable (SBP, DBP, MAP) or hypertension. No significant interactions were found between PAI-1 genotype and BMI or PAI-1 genotype and PA for any BP variable (SBP, DBP, MAP). Overweight and obese subjects had elevated BP (SBP, DBP, MAP) regardless of genotype, whereas normal weight 4G/4G subjects had the highest mean SBP of all normal weight groups. In the lowest tertile of PA, 4G/4G subjects had the highest mean SBP of all groups. When the PAI-1 and ACE genotypes were combined, a significant gene-gene interaction resulted for DBP only. Individuals with the ACE II genotype had the highest mean DBP values across all PAI-1 genotypes.;Conclusions. Overall, these results suggest the PAI-1 4G/5G genotype is not associated with BP or hypertension in Caucasian adults (males and females). We found limited evidence for an interaction between ACE and PAI-1 genotypes on BP variables, with a significant interaction resulting for DBP only. Furthermore, the interaction of PAI-1 genotype with adiposity and PA measures were not significant for any BP variable (SBP, DBP, MAP). However, individuals with the 4G/4G genotype may have elevated SBP, especially when combined with the phenotypes of overweight/obesity and low PA. The association of PAI-1 and ACE genotypes, along with their interactions with adiposity and PA needs to be further studied in a larger sample of adults.
机译：背景。血压（BP）与纤溶酶原激活物抑制剂1（PAI-1）和血管紧张素转换酶（ACE）的血浆水平升高有关。 ACE及其插入/删除（I / D）多态性与BP的关联已得到很好的研究。但是，PAI-1 4G / 5G多态性在PAI-1和BP之间的关联中的作用尚不清楚。此外，诸如肥胖，体力活动（PA）和其他基因等因素可能会影响BP。因此，本研究的目的是研究4G / 5G多态性与BP的关联，以及其与肥胖，身体活动以及ACE I / D多态性在BP上的相互作用。魁北克家庭研究中的815名受试者，包括身高，体重和体重指数（BMI）的有效数据；脂肪百分比PA水平；收缩压，舒张压和平均动脉血压（SBP，DBP，MAP）;分析基因型和基因型。 PAI-1 4G / 5G基因型与任何BP变量（SBP，DBP，MAP）或高血压无关。对于任何BP变量（SBP，DBP，MAP），PAI-1基因型与BMI或PAI-1基因型与PA之间均未发现明显的相互作用。不论基因型如何，超重和肥胖受试者的BP（SBP，DBP，MAP）均升高，而正常体重的4G / 4G受试者在所有正常体重组中的平均SBP最高。在PA的最低三分位数中，所有组中4G / 4G受试者的平均SBP最高。当PAI-1和ACE基因型合并时，仅DBP产生了显着的基因-基因相互作用。具有ACE II基因型的个体在所有PAI-1基因型中的平均DBP值最高。总体而言，这些结果表明，PAI-1 4G / 5G基因型与白种人成年人（男性和女性）的血压或高血压无关。我们发现BP变量上ACE和PAI-1基因型之间相互作用的证据有限，仅DBP会产生显着相互作用。此外，对于任何BP变量（SBP，DBP，MAP），PAI-1基因型与肥胖和PA的相互作用均不显着。但是，具有4G / 4G基因型的个体的SBP可能升高，尤其是与超重/肥胖和低PA的表型结合时。 PAI-1和ACE基因型的关联，以及它们与肥胖和PA的相互作用，需要在更大的成年人样本中进一步研究。

著录项

  • 作者

    Sarzynski, Mark Andrew.;

  • 作者单位

    Michigan State University.;

  • 授予单位 Michigan State University.;
  • 学科 Health Sciences Recreation.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 130 p.
  • 总页数 130
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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