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首页> 外文期刊>Genetic Testing >Association of PAI-1 4G/5G and -844G/A Gene Polymorphisms and Changes in PAI-1/Tissue Plasminogen Activator Levels in Myocardial Infarction: A Case-Control Study
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Association of PAI-1 4G/5G and -844G/A Gene Polymorphisms and Changes in PAI-1/Tissue Plasminogen Activator Levels in Myocardial Infarction: A Case-Control Study

机译：心肌梗死中PAI-1 4G / 5G和-844G / A基因多态性与PAI-1 /组织纤溶酶原激活剂水平变化的关联：病例对照研究

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摘要

Background: Myocardial infarction (MI) is induced by acquired and inherited risk factors, including the plasminogen activator inhibitor-1 (PAI-1) -844G/A and -675G/A (4G/5G) gene variants. Objective: The aim of this study was to investigate the association between PAI-1-844G/A and 4G/5G polymorphisms and changes in PAI-1 and tissue plasminogen activator (tPA) levels in MI in a Tunisian population. Methods: This was a case-control study involving 305 patients with MI and 328 unrelated healthy controls. PAI-1 genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP) (-844G/A) or by polymerase chain reaction-allele specific amplification. PAI-1 and tPA levels were assayed by serological assays. Results: In contrast to tPA levels, mean plasma PAI-1 antigen levels were higher in cases than in control subjects. The elevation in PAI-1 levels was more pronounced in -844A and 4G allele carriers. Significantly higher frequencies of (mutant) 4G and -844A alleles and 4G/4G and -844A/-844A genotypes, and corresponding lower frequencies of (wild-type) 5G and -844G alleles and 5G/5G and -844G/-844G genotypes were seen in patients than in controls. Increased prevalence of 4G/-844A and decreased prevalence of 5G/-844G haplotypes were seen in patients than in controls, thereby conferring a susceptibility and protective nature to these haplotypes, respectively. Regression analysis confirmed the independent association of 4G/4G and -844A/A with MI, after controlling for a number of covariates. Conclusion: This study indicated that the risk of MI was notably high in 4G and -844A carriers with elevated plasma PAI-1 and were associated with reduced tPA levels.
机译：背景：心肌梗塞（MI）是由获得性和遗传性风险因素诱发的，包括纤溶酶原激活物抑制剂1（PAI-1）-844G / A和-675G / A（4G / 5G）基因变异。目的：本研究的目的是研究突尼斯人群中MI的PAI-1-844G / A和4G / 5G多态性与PAI-1和组织纤溶酶原激活物（tPA）水平变化之间的关系。方法：这是一项病例对照研究，涉及305例MI患者和328例无关健康对照者。 PAI-1基因分型通过聚合酶链反应-限制性片段长度多态性（RFLP）（-844G / A）或聚合酶链反应-等位基因特异性扩增来完成。通过血清学测定法测定PAI-1和tPA水平。结果：与tPA水平相比，病例中的平均血浆PAI-1抗原水平高于对照组。 PAI-1水平的升高在-844A和4G等位基因携带者中更为明显。 （突变）4G和-844A等位基因以及4G / 4G和-844A / -844A基因型的频率显着较高，（野生型）5G和-844G等位基因以及5G / 5G和-844G / -844G基因型的对应频率较低在患者中比在对照组中看到。与对照组相比，患者中4G / -844A患病率升高，而5G / -844G单体型患病率降低，从而分别赋予了这些单体型易感性和保护性。回归分析证实，在控制了许多协变量之后，4G / 4G和-844A / A与MI的独立关联。结论：这项研究表明血浆PAI-1升高的4G和-844A携带者发生MI的风险显着，并且与tPA水平降低有关。

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  • 来源
    《Genetic Testing》 |2010年第1期|23-27|共5页
  • 作者

    Nesrine Abboud; Lakhdar Ghazouani; Sarra Saidi; Sonia Ben-Hadj-Khalifa; Fawzi Addad; Wassim Y. Almawi; Touhami Mahjoub;

  • 作者单位

    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;

    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;

    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;

    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;

    Intensive Care Unit of Cardiology, Fattouma Bourguiba Hospital, Monastir, Tunisia;

    Department of Medical Biochemistry College of Medicine and Medical Sciences Arabian Gulf University P.O. Box 22979 Manama 729 Bahrain;

    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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