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首页> 外文期刊>Indian Journal of Endocrinology and Metabolism >A Comparison of clinicopathological characteristics and short-term outcome of papillary thyroid carcinoma with tall cell histology and classic papillary thyroid carcinoma: A single-institution experience
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A Comparison of clinicopathological characteristics and short-term outcome of papillary thyroid carcinoma with tall cell histology and classic papillary thyroid carcinoma: A single-institution experience

机译：高细胞组织学和经典甲状腺乳头状癌的甲状腺乳头状癌临床病理特征和近期预后的比较：单机构经验

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Context: Papillary thyroid carcinoma with tall cell histology (PTC-TCH) is an aggressive subtype in terms of clinicopathological features and outcome. Even 10% of tall cells can show aggressive features. Aims: The aim of this study is to investigate the behavior of PTC-TCH, to compare with classic PTC (cPTC), and evaluate the short-term outcome. Settings and Design: This is a retrospective analysis of patients with cPTC and those with TCH (PTC-TCH) seen from January 2010 to May 2017 seen in our Thyroid Cancer Clinic. Materials and Methods: A total of 40 patients with TCH were compared with 352 cPTC and evaluated for age, gender, tumor size, presence of multifocality, capsular, vascular invasion, extrathyroid extension, and appearance of metastases. Short-term response to therapy was assessed using the 2015 American Thyroid Association guidelines. Statistical Analysis: P Results: PTC with TCH presented at a younger age, had larger tumors, and more extrathyroid extension. Seven out of 40 cases developed lung metastases, (17.5% vs. 4.5% in cPTC), within a year of diagnosis. Conclusion: PTC-TCH irrespective of percentage of tall cells showed aggressive features and early metastases. They should be recognized early as an aggressive subtype and treated intensively. Close follow-up must be instituted to look for metastases, especially to the lungs.
机译：背景：就临床病理特征和预后而言，甲状腺乳头状癌伴高细胞组织学（PTC-TCH）是一种侵略性亚型。甚至10％的高大细胞也可以表现出攻击性特征。目的：本研究的目的是调查PTC-TCH的行为，与经典PTC（cPTC）进行比较，并评估短期结果。设置和设计：这是对2010年1月至2017年5月在我们的甲状腺癌诊所中发现的cPTC和TCH（PTC-TCH）患者的回顾性分析。材料与方法：将40例TCH患者与352 cPTC进行比较，并评估其年龄，性别，肿瘤大小，多灶性，包膜，血管浸润，甲状腺外扩展和转移灶的出现。使用2015年美国甲状腺协会指南评估了对治疗的短期反应。统计分析：P结果：带有TCH的PTC年龄较小，肿瘤较大，甲状腺外延伸更多。在诊断的一年内，每40例中有7例发生了肺转移（17.5％对cPTC中为4.5％）。结论：PTC-TCH与高细胞百分比无关，均显示出侵袭性特征和早期转移。它们应及早被识别为侵略性亚型，并应接受强化治疗。必须进行密切随访以寻找转移，尤其是肺转移。

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