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首页> 外文期刊>Nuclear Medicine Communications >Clinicopathologic features and prognostic factors of tall cell variant of papillary thyroid carcinoma: comparison with classic variant of papillary thyroid carcinoma
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Clinicopathologic features and prognostic factors of tall cell variant of papillary thyroid carcinoma: comparison with classic variant of papillary thyroid carcinoma

机译：甲状腺乳头状癌高细胞变种的临床病理特征和预后因素：与甲状腺乳头状癌经典变种的比较

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ObjectiveTall cell variant (TCV), an aggressive form of papillary thyroid carcinoma (PTC), frequently presents with extrathyroidal disease and recurrence. The aim of this study was to evaluate the clinicopathologic features and outcomes of patients with TCV by comparing them with a larger group of patients with classic variant of papillary thyroid carcinoma (cPTC).Patients and methodsA total of 2500 patients with differentiated thyroid carcinoma were treated and monitored during a 23-year period (1992-2015). Of them, 2250 (90%) had PTC and 235 (9.5%) had follicular thyroid carcinoma. Of the 2250 patients, 862 (38.3%) and 70 (3.1%) had cPTC and TCV, respectively. Cases of TCV and cPTC of PTC were compared on the basis of risk factors.ResultsPatients with TCV were significantly older compared with cPTC patients (P<0.001). Tumor size was significantly bigger (P=0.01) and preablation thyroglobulin level was significantly higher (P<0.001) in TCV patients than in cPTC patients. The incidence of capsule invasion, extrathyroidal extension, and vascular invasion was significantly higher in TCV (P=0.003, <0.001, and 0.011, respectively). The incidence of initial lymph node metastasis was significantly higher in TCV (P<0.001). Patients with TCV were mostly at an advanced stage compared with patients with cPTC (P<0.001). Development of local or distant metastasis during the follow-up was significantly higher in TCV than in cPTC. Sex and multifocality were not statistically significant.ConclusionTCV has a higher incidence of local or distant metastasis and mortality rate. Thus, it must be treated with the highest possible I-131 ablation doses and followed up carefully.
机译：ObjectiveTall细胞变异体（TCV）是甲状腺乳头状癌（PTC）的一种侵袭性形式，经常表现为甲状腺外疾病和复发。这项研究的目的是通过将TCV患者与一大批典型乳头状甲状腺癌（cPTC）变异患者进行比较来评估TCV患者的临床病理特征和结果。患者和方法总共治疗了2500例分化型甲状腺癌患者并在23年内（1992年至2015年）进行了监控。其中，2250（90％）患有PTC，235（9.5％）患有滤泡性甲状腺癌。在2250名患者中，分别有862名（38.3％）和70名（3.1％）患有cPTC和TCV。根据危险因素比较了TCV和PTC的cPTC病例。结果TCV的患者比cPTC的患者年龄大（P <0.001）。与cPTC患者相比，TCV患者的肿瘤大小明显更大（P = 0.01），消融前甲状腺球蛋白水平显着更高（P <0.001）。 TCV的包膜浸润，甲状腺外扩张和血管浸润的发生率显着更高（分别为P = 0.003，<0.001和0.011）。 TCV中初始淋巴结转移的发生率显着更高（P <0.001）。与cPTC患者相比，TCV患者大多处于晚期（P <0.001）。在随访期间，TCV的局部或远处转移的发生明显高于cPTC。性别和多焦点无统计学意义。结论TCV发生局部或远处转移和死亡率的发生率较高。因此，必须使用尽可能高的I-131消融剂量进行治疗，并仔细随访。

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