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首页> 外文期刊>Indian heart journal >Prevalence of metabolic syndrome and its clinical and angiographic profile in patients with naive ACS in North Indian population
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Prevalence of metabolic syndrome and its clinical and angiographic profile in patients with naive ACS in North Indian population

机译：北印度人群初次ACS患者的代谢综合征患病率及其临床和血管造影谱

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Background: Although, there is evidence to support increasedcardiovascular morbidity and mortality in metabolic syndrome(MetS), there is little data available to address the importance ofisolated metabolic syndrome as a risk factor in patients presentingwith ACS especially in context to Indian population. Hence, westudied the prevalence of metabolic syndrome and its clinical andangiographic profile in na?ve ACS (STEMI/NSTEMI) patients inNorth Indian population.Material and methods: Single center, prospective, observationstudy was undertaken in tertiary care centre at Kanpur, NorthIndia in na?ve ACS patients. Metabolic syndrome was definedaccording to modified NCEP-ATP III (2004) criteria. Total numberof patients enrolled were 324 and patients were studied into twogroups (with MetS and without MetS) and their clinical and angiographicprofiles were compared.Results: Overall prevalence of metabolic syndrome in our studywas found as 37.65%. Metabolic syndrome patients with ACS werethree years older than those without metabolic syndrome (60.3 8.4 vs 57.6 7.9, p = 0.07), more likely to be females (35.24% vs24.25%, p = 0.05) and less likely to have tobacco abuse (30.32% vs42.57%, p < 0.001). Patients with MetS were more likely to presentwith NSTEMI (58.19% vs 36.14%, p = 0.003) than STEMI (41.80% vs63.86%, p = 0.002). Although, MetS patients were more likely todevelop cardiogenic shock (27.04% vs 17.32%, p = 0.02) and recurrentischemia (13.93% vs 7.42%, p = 0.01) than those with no MetS,with regard to mortality no difference was observed in both thegroups (6.55% vs 5.44%, p = 0.23). Angiographic profile showedlower preponderance of single vessel disease (SVD) in MetS groupvis-à-vis without MetS group (29.52% vs 55.48%, p = 0.001). However,presence of double vessel disease (DVD), triple vessel disease(TVD), and left main (LMCA) (42.28% vs 23.69%, 22.87% vs 9.82%,12.38% vs 4.04%, p = 0.001) were more common in MetS group thanwithout MetS group. More complex coronary lesion (tubular 42.59%vs 32.76% and diffuse 25.29% vs 15.79%, p = 0.01) were common inMetS group than in patients without MetS group when comparedto simple coronary lesion (discrete 32.12% vs 51.45%, p = 0.01),respectively.Conclusion: Our study has identified the high prevalence of MetSamong patients with ACS in North Indian population. Also there istrend of more advanced vascular damage (depending on number ofvessel and type of lesion involvement) in patients with MetS thanthose without MetS. To the best our knowledge this is first studyfrom North India documenting the angiographic profile of patientswith metabolic syndrome and ACS.
机译：背景：尽管有证据支持代谢综合征（MetS）中心血管疾病的发病率和死亡率增加，但很少有数据可用来解决孤立代谢综合征作为ACS患者的危险因素的重要性，特别是在印度人群中。因此，研究了印度北部幼稚ACS（STEMI / NSTEMI）患者的代谢综合征的发生率及其临床血管造影特征。材料与方法：在印度北部印度坎普的三级医疗中心进行单中心，前瞻性，观察性研究。五名ACS患者。根据修订的NCEP-ATP III（2004）标准定义了代谢综合征。纳入的患者总数为324名，将患者分为两组（有MetS和无MetS），并比较了他们的临床和血管造影照片。结果：本研究中代谢综合征的总体患病率为37.65％。患有ACS的代谢综合征患者比没有代谢综合征的患者大三岁（60.3 8.4 vs 57.6 7.9，p = 0.07），女性更可能（35.24％vs24.25％，p = 0.05）并且吸烟的可能性较小（ 30.32％和42.57％，p <0.001）。与STEMI（41.80％vs63.86％，p = 0.002）相比，MetS患者更容易出现NSTEMI（58.19％vs 36.14％，p = 0.003）。尽管MetS患者比没有MetS的患者更有可能发生心源性休克（27.04％vs 17.32％，p = 0.02）和复发性缺血（13.93％vs 7.42％，p = 0.01），但在死亡率方面，两者均无差异两组（6.55％vs 5.44％，p = 0.23）。血管造影结果显示，MetS组的单支血管疾病（SVD）优势比无MetS组低（29.52％vs 55.48％，p = 0.001）。然而，双血管疾病（DVD），三血管疾病（TVD）和左主干（LMCA）的发生率（42.28％vs 23.69％，22.87％vs 9.82％，12.38％vs 4.04％，p = 0.001）更常见在MetS组比没有在MetS组中。与单纯冠状动脉病变相比，MetS组较无MetS组患者更常见复杂的冠状动脉病变（肾小管42.59％vs 32.76％，弥漫性25.29％vs 15.79％，p = 0.01）（离散型32.12％vs 51.45％，p = 0.01）。结论：我们的研究确定了北印度人群中MetSamong ACS患者的高患病率。与没有MetS的患者相比，MetS患者也有更严重的血管损伤（取决于血管数量和病变累及类型）的趋势。据我们所知，这是北印度的第一项研究，记录了代谢综合征和ACS患者的血管造影情况。

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