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首页> 外文期刊>Indian Journal of Medical Microbiology >Rising trend of antimicrobial resistance among Neisseria gonorrhoeae isolates and the emergence of N. gonorrhoeae isolate with decreased susceptibility to ceftriaxone
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Rising trend of antimicrobial resistance among Neisseria gonorrhoeae isolates and the emergence of N. gonorrhoeae isolate with decreased susceptibility to ceftriaxone

机译：淋病奈瑟菌分离株中抗菌素耐药性上升趋势以及淋病奈瑟菌分离株的出现，对头孢曲松的敏感性降低

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Context: Gonorrhoea is one of the most common sexually transmitted infections (STI) in developing countries and is a global health problem. Aims: To analyze the trend of antimicrobial susceptibility of Neisseria gonorrhoeae isolates over the years, in a tertiary care hospital of North India. Settings and Design: The study population comprised males with urethritis and females with endocervicitis attending STI clinic of our hospital. Materials and Methods: In our STI laboratory, all gonococcal isolates are subjected to antimicrobial susceptibility testing by disc diffusion method as per CLSI guidelines. β-lactamase production is determined by chromogenic cephalosporin test. Minimum Inhibitory Concentration (MIC) for ceftriaxone is determined by E-test. Statistical Analysis Used: Data were expressed as percentages. The differences in percentages were tested for statistical significance by using χ2 test and P values were determined. Results: The percentage of penicillinase producing N. gonorrhoeae (PPNG) increased from 8% in 1995-96 to 20% in 2004-05 and 88% in 2011-2013. Quinolone-resistant N. gonorrhoeae (QRNG) showed a significant increase from 12% in 1995-96 to 98.3% in 2004-05, while 84% isolates were found to be QRNG by 2011-2013. In January 2013 we detected our first gonococcal isolate with decreased susceptibility to third-generation cephalosporins; Ceftriaxone, Cefixime and Cefpodoxime (MIC for ceftriaxone = 0.19 μg/ml). Conclusions: The results of our study highlighted an alarming increase in the percentage of PPNG and QRNG strains over the years. Emergence of N. gonorrhoeae isolates with decreased susceptibility to third-generation cephalosporins is a cause of concern and thus emphasises the importance of antimicrobial susceptibility testing.
机译：背景：淋病是发展中国家最常见的性传播感染（STI）之一，是一个全球性的健康问题。目的：在北印度的一家三级医院中，分析多年来淋病奈瑟氏菌分离株的抗菌药敏感性趋势。设置与设计：研究人群包括男性尿道炎和女性宫颈内膜炎，就诊于我院的STI诊所。材料和方法：在我们的STI实验室中，所有淋球菌分离物均按照CLSI指南通过圆盘扩散法进行了药敏试验。 β-内酰胺酶的产生通过生色头孢菌素试验确定。头孢曲松的最低抑菌浓度（MIC）通过E检验确定。使用的统计分析：数据表示为百分比。使用χ 2 检验检验百分比差异的统计学意义，并确定P值。结果：产生青霉素酶的淋病奈瑟氏球菌（PPNG）的百分比从1995-96年的8％增加到2004-05年的20％和2011-2013年的88％。耐喹诺酮类淋病奈瑟氏球菌（QRNG）从1995-96年的12％显着增加到2004-05年度的98.3％，而到2011-2013年发现84％的分离株为QRNG。 2013年1月，我们检测到第一个对第三代头孢菌素敏感性降低的淋球菌分离株;头孢曲松，头孢克肟和头孢泊肟（头孢曲松的MIC = 0.19μg/ ml）。结论：我们的研究结果突显了多年来PPNG和QRNG菌株百分比的惊人增长。对第三代头孢菌素敏感性降低的淋病奈瑟氏球菌分离株的出现引起人们的关注，因此强调了抗菌素敏感性测试的重要性。

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