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首页> 外文期刊>Indian Journal of Medical Microbiology >Central line-associated bloodstream infections in cancer patients: An experience from a tertiary care cancer centre
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Central line-associated bloodstream infections in cancer patients: An experience from a tertiary care cancer centre

机译：癌症患者中与中心线相关的血液感染：三级癌症中心的经验

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Introduction: Central venous catheters (CVCs) implanted in patients with malignancies may often be associated with local or central line-associated bloodstream infections (CLABSI), which are a major source of morbidity and rarely mortality, making such patients' care difficult and complicated. Materials and Methods: This retrospective study is a single-centre's experience including both paediatric and adult patients with malignancy, who had a CVC inserted and were receiving care at cancer centre of our hospital over a period between January 2017 and June 2018. Results: In the period from January 2017 to June 2018, 73 confirmed cases of CLABSIs among cancer patients were included in this study. The rate of CLABSIs was estimated as 2.1 episodes/1000 CVC days. Out of 73 CLABSI cases, Gram-negative bacilli were the predominant causative agents of CLABSI constituting 72.6% (n = 53/73) of isolated organisms, 21.9% (n = 16/73) of infections were caused by Gram-positive cocci while polymicrobial infections accounted for 5.4% (n = 4/73) of these cases. Conclusion: Over the last 20 years, an epidemiologic shift has occurred among CLABSI in cancer patients. These findings should be considered with the development of interventions that will prevent Gram-negative CLABSI after CVC insertion. To our knowledge, this is the first study reporting data on the incidence of CLABSIs in cancer patients at tertiary care hospital from North Indian hospital.
机译：简介：植入恶性肿瘤患者的中央静脉导管（CVC）可能经常与局部或中央线相关的血流感染（CLABSI）相关，后者是发病率的主要来源，很少发生死亡，这使得此类患者的护理困难而复杂。资料和方法：这项回顾性研究是单中心的经验，包括儿童和成人恶性肿瘤患者，他们均已插入CVC并在2017年1月至2018年6月期间在我们医院的癌症中心接受治疗。在2017年1月至2018年6月期间，本研究纳入了73例确诊为癌症患者的CLABSIs病例。 CLABSI发生率估计为2.1发作/ 1000 CVC天。在73例CLABSI病例中，革兰氏阴性杆菌是CLABSI的主要病原体，占分离菌的72.6％（n = 53/73），21.9％（n = 16/73）的感染是由革兰氏阳性球菌引起的，而多微生物感染占这些病例的5.4％（n = 4/73）。结论：在过去的20年中，CLABSI在癌症患者中发生了流行病学转变。应当采取干预措施，以防止在插入CVC后出现革兰氏阴性CLABSI。据我们所知，这是北印度医院三级医院报道癌症患者中CLABSI发生率的第一项研究数据。

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