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首页> 外文期刊>Indian journal of nephrology >“Ico-Alone” single nocturnal exchange to initiate peritoneal dialysis in patients with residual renal function–Five year, single centre experience
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“Ico-Alone” single nocturnal exchange to initiate peritoneal dialysis in patients with residual renal function–Five year, single centre experience

机译：“ Ico-Alone”单次夜间交换可在残存肾功能的患者中进行腹膜透析–五年，单中心经验

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We analyzed the outcome of incremental dialysis with single nocturnal icodextrin exchange peritoneal dialysis (PD) as the initial treatment for end-stage kidney failure in patients who have significant residual renal function. All adult patients opting for PD as renal replacement therapy, having residual renal function, and urinary KT/V of 1.0 were offered incremental dialysis with single nocturnal icodextrin exchange as initial treatment. Adequacy of dialysis was calculated at 1, 3, and 6 months and then 6 monthly. Patients were shifted to conventional PD if short of adequacy or if clinically indicated. Median period on “Ico-alone,” peritonitis, exit site infection rates, and patient survival, while on this protocol, were calculated. These outcomes were compared with the cohort of contemporary patients on conventional PD. Thirteen patients were initiated on “Ico-alone” dialysis between October 2006 and October 2011. The baseline characteristics were similar when compared with cohort of conventional PD patients, except urine volume, which was more in “Ico-alone” group (1265 ± 316 vs. 551 ± 504, P = 0.000). Total KT/V at 3 months (1.63 ± 0.6 vs. 1.7 ± 0.2, P = 0.6) and at 1 year (1.64 ± 0.5 vs. 1.53 ± 0.3, P = 0.6) was similar to the cohort of conventional PD patients. Median period on “Ico-alone” was 9.6 months. Peritonitis rate was 1 episode in 56.22 vs 25.29 patient-months and exit site infection was 1 episode in 56.2 vs 189.71 patient-months in “Ico-alone” and conventional group, respectively. Patient survival was 42.84 months in “Ico-alone” vs 25.29 months in conventional dialysis (P = 0.01). In conclusion, single icodextrin exchange offers adequate dialysis in patients with residual renal function (KT/V = 1) for a median period of 9 months.Keywords: Icodextrin, incremental dialysis, peritoneal dialysis
机译：我们分析了单次夜间艾考糊精交换腹膜透析（PD）作为具有显着残余肾功能的患者终末期肾衰竭的初始治疗而进行的增量透析的结果。所有接受PD替代肾替代治疗，残存肾功能，尿KT / V为1.0的成年患者均需进行增量透析，并进行一次夜间艾考糊精交换作为初始治疗。分别在1、3和6个月，然后每月6个月计算透析的充分性。如果不足或临床指示，则将患者转为常规PD。根据该协议，计算了“仅Ico”，腹膜炎，出口部位感染率和患者存活率的中位时间。将这些结果与传统PD患者的队列比较。在2006年10月至2011年10月之间，有13例患者开始接受“ Ico-alone”透析。与常规PD患者队列相比，基线特征相似，只是尿量有所增加，“ Ico-alone”组的尿液量更大（1265±316）与551±504，P = 0.000）。 3个月时（1.63±0.6 vs. 1.7±0.2，P = 0.6）和1年时（1.64±0.5 vs. 1.53±0.3，P = 0.6）的总KT / V与传统PD患者的队列相似。 “独立”的中位时间为9.6个月。在“ Ico-alone”组和常规组中，腹膜炎发生率分别为56.22 vs.25.29患者-月的1次发作和56.2 vs 189.71患者-月的出口部位感染。 “仅Ico”患者的生存期为42.84个月，而常规透析为25.29个月（P = 0.01）。综上所述，单次艾考糊精交换可为残存肾功能（KT / V = 1）的患者提供足够的透析，中位时间为9个月。关键词：艾考曲宁，增量透析，腹膜透析

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