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首页> 外文期刊>Indian Journal of Nuclear Medicine >Metachronous second primary malignancies in known breast cancer patients on 18F-fluoro-2-deoxyglucose positron emission tomography–computerized tomography in a tertiary care Center
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Metachronous second primary malignancies in known breast cancer patients on 18F-fluoro-2-deoxyglucose positron emission tomography–computerized tomography in a tertiary care Center

机译：三级护理中心的18F-氟-2-脱氧葡萄糖正电子发射断层显像-计算机断层摄影术中已知乳腺癌患者的同期第二原发恶性肿瘤

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Introduction: Breast cancer is the most common malignancy among women all over the world, which accounts to 25% of all cancers. In known cases of breast cancer, the risk of developing another denovo malignancy is more when compared to low risk groups, which might be due to common environmental risk factors, treatment induced risk factors, Genetic susceptibility for mutations, presence of cancer syndromes or better detection due to close surveillance. Objective: To study the profile of Metachronous 2supnd/sup primary malignancies suspected on 18F-FDG PET CT in known Breast cancer patients. In this Retrospective study from January 2014 to April 2018, all the consecutive patients with known Breast cancer, who were referred to Nuclear Medicine department for 18F- FDG PET CT for follow up evaluation were included. Suspected 2supnd/sup primary malignancies were correlated with Histopathological examination (HPE). Results: During the study period, a total of 233 Breast cancer patients (all are females), with a mean age of 54.2+13.4 years were studied. On 18F-FDG PET CT scan, suspicion for 2supnd/sup primary malignancy was observed in 37 patients. HPE was done in 28/37 patients at the site of suspected lesions. 15/28 were positive for second malignancy, and remaining 13/28 were either a benign pathology or a part of metastatic disease from the primary breast cancer. The sites of 2supnd/sup primary malignancies included Contralateral breast in 8/15 (53.3%), Ovary in 2/15 (13.3%), Endometrium in 2/15 (13.3%), Lung in 1/15 (6.6%), Stomach in 1/15 (6.6%) and Urinary bladder in 1/15 (6.6%) patients respectively. The incidence of metachronous 2supnd/sup primaries in breast cancer is 67.3 per 1000 breast cancer patients. Conclusion: Metachronous second primary cancers in breast cancer patients are not very rare. A high imaging suspicion on 18F-FDG PET CT helps in early detection of 2supnd/sup primary cancer, thereby facilitating early and appropriate management.
机译：简介：乳腺癌是全世界女性中最常见的恶性肿瘤，占所有癌症的25％。在已知的乳腺癌病例中，与低风险人群相比，发生另一种登革热恶性肿瘤的风险更大，这可能是由于常见的环境风险因素，治疗引起的风险因素，遗传易感性突变，癌症综合征的存在或更好的检测由于受到密切监视。目的：研究已知的乳腺癌患者在18F-FDG PET CT上怀疑的异时性2 原发性恶性肿瘤的概况。在这项2014年1月至2018年4月的回顾性研究中，纳入了所有连续已知乳腺癌的患者，这些患者被转诊至核医学科进行18F-FDG PET CT的随访评估。疑似2 原发性恶性肿瘤与组织病理学检查（HPE）相关。结果：在研究期间，共研究了233例乳腺癌患者（均为女性），平均年龄为54.2 + 13.4岁。在18F-FDG PET CT扫描中，在37例患者中怀疑有2 原发性恶性肿瘤。在疑似病变部位对28/37例患者进行了HPE。 15/28为第二恶性肿瘤阳性，其余13/28为良性病理或部分原发性乳腺癌转移性疾病。 2 原发性恶性肿瘤的部位包括：对侧乳腺在8/15（53.3％），子房在2/15（13.3％），子宫内膜在2/15（13.3％），肺在1 /分别为15（6.6％），1/15（6.6％）的胃和1/15（6.6％）的膀胱的患者。乳腺癌异源2 原发的发生率为每1000名乳腺癌患者67.3例。结论：乳腺癌患者中异时性第二原发癌并不罕见。对18F-FDG PET CT的高度影像怀疑可帮助及早发现2 原发癌，从而有助于早期和适当的治疗。

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