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首页> 外文期刊>Indian Journal of Nuclear Medicine >Diagnostic importance of contrast enhanced 18 F-fluorodeoxyglucose positron emission computed tomography in patients with tumor induced osteomalacia: Our experience
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Diagnostic importance of contrast enhanced 18 F-fluorodeoxyglucose positron emission computed tomography in patients with tumor induced osteomalacia: Our experience

机译：造影剂增强18 F-氟脱氧葡萄糖正电子发射计算机断层扫描对肿瘤诱发的骨软化症的诊断重要性：我们的经验

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Aims and Objectives: To assess the diagnostic utility of contrast-enhanced 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-ceCT) in localization of tumors in patients with clinical diagnosis of tumor-induced osteomalacia (TIO), in correlation with histopathological results. Materials and Methods: Eight patients (five male and three female) aged 24-60 (mean 42) years with a clinical diagnosis of TIO were included in this prospective study. They underwent whole body (head to toe) FDG PET-ceCT following a standard protocol on Philips GEMINI TF PET-CT scanner. The FDG PET-ceCT results were correlated with postoperative histology findings and clinical follow-up. Results: All the patients had an abnormal PET-ceCT study. The sensitivity of PET-ceCT was 87.5%, and positive predictive value was 100%. The tumor was located in the craniofacial region in 6/8 patients and in bone in 2/8 patients. Hemangiopericytoma was the most common reported histology. All patients underwent surgery, following which they demonstrated clinical improvement. However, one patient with atypical findings on histology did not show any clinical improvement, hence, underwent 68 Gallium-DOTANOC PET-ceCT scan for relocalization of the site of the tumor. Conclusion: The tumors causing TIO are small in size and usually located in obscure sites in the body. Hence, head to toe protocol should be followed for FDG PET-ceCT scans with the inclusion of upper limbs. Once the tumor is localized, regional magnetic resonance imaging can be performed for better characterization of soft tissue lesion. Imaging with FDG PET-ceCT plays an important role in detecting the site of the tumor and thereby facilitating timely management.
机译：目的和目的：评估对比增强型 18 F-氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描（FDG PET-ceCT）在临床上诊断肿瘤性骨​​软化症的患者中的定位（TIO）与组织病理学结果相关。资料与方法：这项前瞻性研究包括八名年龄在24-60岁（平均42岁）且临床诊断为TIO的患者（五名男性和三名女性）。按照飞利浦GEMINI TF PET-CT扫描仪上的标准规程，对他们进行了从头到脚的FDG PET-ceCT全身检查。 FDG PET-ceCT结果与术后组织学检查结果和临床随访相关。结果：所有患者PET-ceCT研究均异常。 PET-ceCT的敏感性为87.5％，阳性预测值为100％。肿瘤位于6/8例患者的颅面部区域，而2/8例患者位于颅骨区域。血管周细胞瘤是最常见的组织学报告。所有患者均接受手术治疗，随后临床表现得到改善。然而，一名在组织学上具有非典型性发现的患者并未表现出任何临床改善，因此，进行了 68 镓-DOTANOC PET-ceCT扫描以重新定位肿瘤部位。结论：引起TIO的肿瘤体积较小，通常位于体内晦涩的部位。因此，FDG PET-ceCT扫描应遵循从头到脚的规程，包括上肢。一旦肿瘤定位，就可以进行区域磁共振成像以更好地表征软组织病变。用FDG PET-ceCT成像在检测肿瘤部位并因此促进及时治疗方面起着重要作用。

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