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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Expression and clinical significance of B and T lymphocyte attenuator on CD4+ and CD8+ T cells from patients with pulmonary tuberculosis
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Expression and clinical significance of B and T lymphocyte attenuator on CD4+ and CD8+ T cells from patients with pulmonary tuberculosis

机译：B和T淋巴细胞减毒剂在肺结核患者CD4 +和CD8 + T细胞中的表达及其临床意义

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Background: As an immune checkpoint, upregulation of B and T lymphocyte attenuator (BTLA) contributes to T-cell exhaustion in chronic infection. However, the characteristics of BTLA on T cells of patients with pulmonary tuberculosis (PTB) are still uncovered. Aims: The aim of the study was to elucidate the dynamics and clinical significance of BTLA expression on circulating CD4sup+/sup and CD8sup+/sup T cells of PTB patients. Materials and Methods: BTLA expression on T cells from PTB patients with smear positivity (n = 86) and healthy controls (HCs) (n = 40) were determined using flow cytometry. Results: The levels of BTLA expression on circulating CD4sup+/sup and CD8sup+/sup T cells of PTB patients with smear positivity were both upregulated, compared with HC. At the same time, the levels of BTLA expression on CD4sup+/sup and CD8sup+/sup T cells of patients with retreatment were both higher than that of those with initial treatment and gradually upregulated along with the increase of the bacillary load in sputum. In addition, the patients with lung cavity were discovered to present higher levels of BTLA expression on CD4sup+/sup and CD8sup+/sup T cells than those without lung cavity. Whereas we noted that there was no correlation between the levels of BTLA expression and the positivity or negativity of anti-Mycobacterium tuberculosis antibody. Conclusions: The levels of BTLA expression were upregulated on CD4sup+/sup and CD8sup+/sup T cells of PTB patients and associated with disease progression. Thereby, BTLA expression on T cells may be considered as a potential clinical indicator and utilized as a therapeutic target for PTB.
机译：背景：作为免疫检查点，B和T淋巴细胞衰减剂（BTLA）的上调有助于慢性感染中T细胞的衰竭。然而，仍未发现肺结核（PTB）患者T细胞上BTLA的特征。目的：研究目的在于阐明BTLA在PTB患者的循环CD4 + 和CD8 + T细胞中的表达动态及其临床意义。材料和方法：使用流式细胞术确定涂片阳性（n = 86）和健康对照（HCs）（n = 40）的PTB患者T细胞上的BTLA表达。结果：与HC相比，涂阳的PTB患者的循环CD4 + 和CD8 + T细胞上的BTLA表达水平均被上调。同时，复治患者CD4 + 和CD8 + T细胞上的BTLA表达水平均高于初治患者，并逐渐上调。随着痰中细菌量的增加。此外，发现有肺腔的患者在CD4 + 和CD8 + T细胞上的BTLA表达水平高于没有肺腔的患者。而我们注意到BTLA表达水平与抗结核分枝杆菌抗体的阳性或阴性之间没有相关性。结论：PTTB患者CD4 + 和CD8 + T细胞上BTLA表达水平上调，与疾病进展有关。因此，T细胞上的BTLA表达可以被认为是潜在的临床指标，并被用作PTB的治疗靶标。

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