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首页> 外文期刊>Indian Pacing and Electrophysiology Journal >A Case for Pharmacogenomics in Management of Cardiac Arrhythmias
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A Case for Pharmacogenomics in Management of Cardiac Arrhythmias

机译：药物基因组学在心律失常管理中的一例

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Disorders of the cardiac rhythm are quite prevalent in clinical practice. Though the variability in drug response between individuals has been extensively studied, this information has not been widely used in clinical practice. Rapid advances in the field of pharmacogenomics have provided us with crucial insights on inter-individual genetic variability and its impact on drug metabolism and action. Technologies for faster and cheaper genetic testing and even personal genome sequencing would enable clinicians to optimize prescription based on the genetic makeup of the individual, which would open up new avenues in the area of personalized medicine. We have systematically looked at literature evidence on pharmacogenomics markers for anti-arrhythmic agents from the OpenPGx consortium collection and reason the applicability of genetics in the management of arrhythmia. We also discuss potential issues that need to be resolved before personalized pharmacogenomics becomes a reality in regular clinical practice.
机译：心律失常在临床实践中非常普遍。尽管已经广泛研究了个体之间药物反应的变异性，但是该信息尚未在临床实践中广泛使用。药物基因组学领域的快速发展为我们提供了关于个体间遗传变异及其对药物代谢和作用影响的重要见解。用于更快，更便宜的基因测试甚至个人基因组测序的技术将使临床医生能够根据个体的基因组成优化处方，这将为个性化医学领域开辟新途径。我们系统地研究了OpenPGx协会收集的抗心律不齐药物的药物基因组学标记的文献证据，并阐明了遗传学在心律失常管理中的适用性。我们还将讨论在常规临床实践中实现个性化药物基因组学成为现实之前需要解决的潜在问题。

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