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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Ki-67 and Bcl-2 in colorectal polyps with breast cancer
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Ki-67 and Bcl-2 in colorectal polyps with breast cancer

机译：结肠直肠息肉与乳腺癌中的Ki-67和Bcl-2

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Background: The most common second primary cancer in women who survive breast cancer is colorectal cancer. Population cohort studies suggest that the risk of colorectal cancer is also high in female relatives of women with breast cancer compared to the general population. The histological distinction between a large hyperplastic polyp and a serrated adenoma is not straightforward and there is probably no sharp division between hyperplastic polyposis and 'serrated adenomatous polyposis'. Aim: The aim of the study was to define the distribution of Ki-67 and Bcl-2 protein in hyperplastic colorectal polyps of women with breast cancer. Materials and Methods: A cross-sectional, controlled study was conducted in 40 women with and without breast cancer who had hyperplastic colorectal polyps. The patients were divided into two groups: Group A (a control group of women without breast cancer, n = 20) and Group B (a study group of women with breast cancer, n = 20). The expression of Ki-67 and Bcl-2 protein was assessed on the basis of quantity of immunostaining, by counting antigen positive cells, in comparison with normal mucosa. Student's t-test and the chi-square test were used to analyse Ki-67 and Bcl-2 expression, respectively. Results: Statistical significance was established at P 0.05. The mean percentage of Ki-67 stained nuclei in Groups A and B was 25.11 ± 2.07 and 41.51 ± 1.86, respectively (P 0.003), whereas the percentage of cases with cells expressing Bcl-2 in Groups A and B was 15% and 85%, respectively (P 0.002). Conclusions: In the present study, greater proliferative activity and greater expression of the antiapoptotic protein Bcl-2 was found in the hyperplastic colorectal polyps of women with breast cancer.
机译：背景：在乳腺癌中幸存的女性中最常见的第二原发癌是结直肠癌。人群队列研究表明，与普通人群相比，罹患乳腺癌的女性亲属中结直肠癌的风险也较高。大型增生性息肉和锯齿状腺瘤之间的组织学区别并不直接，增生性息肉和“锯齿状腺瘤性息肉”之间可能没有明显的区分。目的：本研究旨在确定Ki-67和Bcl-2蛋白在乳腺癌女性增生性结直肠息肉中的分布。材料和方法：一项横断面对照研究是对40名患有增生性大肠息肉的乳腺癌患者进行的。将患者分为两组：A组（无乳腺癌女性对照组，n = 20）和B组（乳腺癌女性研究组，n = 20）。与正常粘膜相比，通过计数抗原阳性细胞，基于免疫染色的量来评估Ki-67和Bcl-2蛋白的表达。用学生t检验和卡方检验分别分析Ki-67和Bcl-2表达。结果：统计学显着性建立在P <0.05。 A和B组中Ki-67染色核的平均百分比分别为25.11±2.07和41.51±1.86（P <0.003），而A和B组中表达Bcl-2的细胞的百分比为15％，而分别为85％（P <0.002）。结论：在本研究中，在乳腺癌女性增生性结肠息肉中发现了更大的增殖活性和抗凋亡蛋白Bcl-2的更高表达。

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