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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Expression and clinicopathological significance of antiapoptotis protein survivin in gallbladder cancer
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Expression and clinicopathological significance of antiapoptotis protein survivin in gallbladder cancer

机译：抗凋亡蛋白survivin在胆囊癌中的表达及其临床病理意义

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Background: Clinical significance of survivin (antiapoptosis protein) in gallbladder cancer is not yet established. Aims: This study was performed to assess the expression pattern of survivin in benign and malignant gallbladder lesions using immunohistochemistry (IHC), and to assess its clinicopathological significance. Settings and Design: Prospective study from July 2012 to July 2014 was performed as a part of intramural research project. Materials and Methods: Tissue samples from resected gallbladder for cholelithiasis (n = 27) and carcinoma gallbladder (n= 24) were evaluated for survivin expression by IHC using a scoring system. Their expression was correlated with different clinicopathological parameters. Statistical Analysis: Fisher's exact test, Student's t-test, and Chi-square test were used as appropriate for data analysis. Kaplan–Meier methods were used to calculate overall and disease-free survival rates among different groups. Two-sided PResults: Benign group (19 females, age [mean ± standard deviation [SD] 45 ± 14 years) and malignant group (20 females, age [mean ± SD] 48.9 ± 13.4 years) were comparable with respect to menopausal status, presence, size and types of stones. However, survivin expression was significantly higher (66.7%, 95% confidence interval [CI] 24–75) in gallbladder cancer than in cholelithiasis group (33%, CI 46–83), P= 0.025). Its expression did not correlate with gender, age, menopausal status, presence of gallstones or their size, number and type, tumor differentiation, and tumor stage. Conclusions: Significantly higher expression of survivin protein in gallbladder cancer as compared to cholelithiasis group suggests its role in gallbladder carcinogenesis though it may not have prognostic value.
机译：背景：尚无生存激素（抗凋亡蛋白）在胆囊癌中的临床意义。目的：本研究旨在通过免疫组化（IHC）评估survivin在良性和恶性胆囊病变中的表达模式，并评估其临床病理学意义。设置与设计：作为壁内研究项目的一部分，进行了2012年7月至2014年7月的前瞻性研究。材料和方法：使用评分系统，通过IHC对胆囊结石切除术（n = 27）和癌胆囊癌（n = 24）的组织样本中survivin表达进行评估。它们的表达与不同的临床病理参数相关。统计分析：费舍尔精确检验，学生t检验和卡方检验用于数据分析。 Kaplan–Meier方法用于计算不同人群之间的总体生存率和无病生存率。双面结果：良性组（19名女性，年龄[平均值±标准差[SD] 45±14岁]）和恶性组（20名女性，年龄[平均值±SD] 48.9±13.4岁）在绝经状态方面具有可比性的存在，大小和类型。但是，胆囊癌中survivin表达明显高于胆石症组（33％，CI 46-83）（66.7％，95％置信区间[CI] 24-75）（P = 0.025）。其表达与性别，年龄，绝经状态，胆结石的存在或其大小，数量和类型，肿瘤分化和肿瘤分期无关。结论：与胆石症组相比，胆囊癌中survivin蛋白的表达明显更高，表明其在胆囊癌发生中的作用虽然可能没有预后价值。

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