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首页> 外文会议>Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on >Expressions of CD151, Integrin alpha3 beta1 and MMP7 in Breast Cancer Tissue Microarray and their Clinicopathological Significance
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Expressions of CD151, Integrin alpha3 beta1 and MMP7 in Breast Cancer Tissue Microarray and their Clinicopathological Significance

机译：CD151，整合素α3β1和MMP7在乳腺癌组织微阵列中的表达及其临床病理意义

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Purpose: CD151, one of tetraspanins has been suggested to regulate cancer invasion and metastasis. We examined whether it is expressed in primary breast carcinoma and whether has relation with integrina3e1 and MMP7. Methods: By using immunohisto chemical S-P method, the expressions of CD151, integrina3e1 and MMP7 proteins in breast cancer tissue micro array (TMA) were tested. Their correlations with clinicopathological features were analyzed. The relationship among three proteins was also analyzed. Comparison between qualitative data was performed using Chi-square test. Results: The positive rates of CD151, integrina3e1 and MMP7 expressions were 0.0% (0/39) , 7.7%(3/39)and 10.3% (4/39) in normal breast tissue, respectively, 33.3% (10/30) , 30%(9/30) and 40.0% (12/30) in tissues of carcinoma in situ, respectively, 59.0%(59/100), 70.0%(70/100) and 70.0% (70/100) in cancerous tissues, respectively. The differences of three kinds of protein expression rates among the three groups were significant (?2 =41.276, ?2=48.618, ?2 =41.801). The expressions of three proteins in breast cancer tissues weren''t associated with patient''s ages and the histological type (P>0.05). But they significantly related with differentiated degree of cancer tissue, lymph node metastasis and TNM stage (p
机译：目的：CD151是四跨膜蛋白之一，已被建议调节癌症的侵袭和转移。我们检查了它是否在原发性乳腺癌中表达，以及是否与integrina3e1和MMP7相关。方法：采用免疫组织化学S-P法检测乳腺癌组织微阵列（TMA）中CD151，integrina3e1和MMP7蛋白的表达。分析了它们与临床病理特征的相关性。还分析了三种蛋白质之间的关系。使用卡方检验进行定性数据之间的比较。结果：正常乳腺组织中CD151，integrina3e1和MMP7表达的阳性率分别为0.0％（0/39），7.7％（3/39）和10.3％（4/39），为33.3％（10/30）。 ，分别在原位癌组织中占30％（9/30）和40.0％（12/30），在癌组织中分别占59.0％（59/100），70.0％（70/100）和70.0％（70/100）组织。三组中三种蛋白质表达率的差异是显着的（？2 = 41.276，？2 = 48.618，？2 = 41.801）。乳腺癌组织中三种蛋白的表达与患者的年龄和组织学类型无关（P> 0.05）。但它们与癌组织的分化程度，淋巴结转移和TNM分期显着相关（p

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