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首页> 外文会议>International Conference on Biomedical Engineering and Biotechnology >Expressions of CD151, Integrin alpha3 beta1 and MMP7 in Breast Cancer Tissue Microarray and their Clinicopathological Significance
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Expressions of CD151, Integrin alpha3 beta1 and MMP7 in Breast Cancer Tissue Microarray and their Clinicopathological Significance

机译：CD151，整合素α3β1和MMP7在乳腺癌组织微阵列中的表达及其临床病理意义

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Purpose: CD151, one of tetraspanins has been suggested to regulate cancer invasion and metastasis. We examined whether it is expressed in primary breast carcinoma and whether has relation with integrina3e1 and MMP7. Methods: By using immunohisto chemical S-P method, the expressions of CD151, integrina3e1 and MMP7 proteins in breast cancer tissue micro array (TMA) were tested. Their correlations with clinicopathological features were analyzed. The relationship among three proteins was also analyzed. Comparison between qualitative data was performed using Chi-square test. Results: The positive rates of CD151, integrina3e1 and MMP7 expressions were 0.0% (0/39) , 7.7%(3/39)and 10.3% (4/39) in normal breast tissue, respectively, 33.3% (10/30) , 30%(9/30) and 40.0% (12/30) in tissues of carcinoma in situ, respectively, 59.0%(59/100), 70.0%(70/100) and 70.0% (70/100) in cancerous tissues, respectively. The differences of three kinds of protein expression rates among the three groups were significant (?2 =41.276, ?2=48.618, ?2 =41.801). The expressions of three proteins in breast cancer tissues weren't associated with patient's ages and the histological type (P>0.05). But they significantly related with differentiated degree of cancer tissue, lymph node metastasis and TNM stage (p
机译：目的：已经提出了一种噻吩咐噻吩，以调节癌症侵袭和转移。我们检查了它是否在原发性乳腺癌中表达，以及是否与Integrina3E1和MMP7有关系。方法：通过使用免疫组合化学S-P方法，测试CD151，Integlein3E1和MMP7蛋白在乳腺癌组织微阵（TMA）中的表达。分析了它们与临床病理学特征的相关性。还分析了三种蛋白质之间的关系。使用Chi-Square测试进行定性数据之间的比较。结果：CD151，Integn3E1和MMP7表达的阳性率分别为正常乳腺组织的0.0％（0/39），7.7％（3/39）和10.3％（4/39），33.3％（10/30） ，分别为癌癌组织30％（9/30）和40.0％（12/30），分别为59.0％（59/100），70.0％（70/100）和70.0％（70/100）的癌症组织分别。三组三种蛋白表达率的差异是显着的（？2 = 41.276，Δ2= 48.618，？2 = 41.801）。乳腺癌组织中三种蛋白质的表达与患者的年龄和组织学型无关（P> 0.05）。但它们与癌组织，淋巴结转移和TNM阶段的分化显着相关（P

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