目的探讨CD151和整合素α3在结肠癌中的表达及临床意义。方法采用免疫组化SP法检测40例结肠炎组织、96例结肠癌组织中CD151及整合素α3的表达，并分析其相关性。结果结肠炎组织和结肠癌组织中CD151表达阳性率分别为0、88.5%；有淋巴结转移组和无淋巴结转移组中CD151表达阳性率分别为100％、63.3%；远处转移组和无远处转移组中CD151表达阳性率分别为100％、78.0%，差异均有统计学意义（均P＜0.05）；在结肠炎组织和结肠癌中整合素α3表达阳性率分别为0、87.5%；有淋巴结转移组和无淋巴结转移组表达阳性率分别为100％、60.0%；远处转移组和无远处转移组中表达阳性率分别为100％、76.0%，差异均有统计学意义（均P＜0.05）。CD151和整合素α3的表达阳性率在结肠癌患者的年龄、性别、肿瘤大小、组织学分型及分化程度中的差异均无统计学意义（均P＞0.05），而在有无淋巴结转移和远处转移中的差异有统计学意义（P＜0.05）。结论CD151和整合素α3的高表达与结肠癌的发生和转移有关，检测CD151和整合素α3的表达可能为结肠癌的诊断、预后判断及治疗提供参考依据。%Objective To investigate the expression and clinical significance of CD151 and integrinα3 in colorectal car-cinoma and its clinicopathological significance. Methods The expressions of CD151 and integrinα3 were examined by using immunohistochemistry in tissue sections from 40 cases of colonitis and 96 cases of colorectal carcinoma. Results The positive rates of CD151 in colonitis and colorectal carcinoma tissues were 0.0%(0/40) and 88.5%(85/96), respectively;in colorectal carci-noma with lymph node metastasis and those without lymph node metastasis were 100.0%(66/66) and 63.3%(19/30), respectively;in colorectal carcinoma with distant metastasis and those without distant metastasis were 100.0%(46/46) and 78.0%(39/50), re-spectively (al P<0.05). The positive rates of integrinα3 in colonitis and colorectal carcinoma tissue were 0.0%(0/40) and 87.5%(84/96), respectively;in colorectal carcinoma with lymph node metastasis and those without lymph node metastasis were 100.0%(66/66) and 60.0%(18/30), respectively;in colorectal carcinoma with distant metastasis and those withour distant metastasis were 100.0%(46/46) and 76.0%(38/50), respectively (al P<0.05). The expression of CD 151 and integrinα3 was not correlated with age, gender, tumor size, pathological types and differentiation of colorectal carcinoma (al P>0.05), while closely correlated with lymph node metastasis and distant metastasis. Conclusion Detection of CD151 and integrinα3 may be of value in diagnosis, prognosis and treatment monitoring of colorectal carcinoma.
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