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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Immunophenotypic profile of plasma cell leukemia: A retrospective study in a reference cancer center in India and review of literature
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Immunophenotypic profile of plasma cell leukemia: A retrospective study in a reference cancer center in India and review of literature

机译：浆细胞白血病的免疫表型特征：在印度参考癌症中心的回顾性研究和文献综述

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Background: Plasma cell leukemia (PCL) is a rare but aggressive subtype of plasma cell dyscrasia. It is known to present with highly variable morphological features and may mimic with other lymphoid neoplasms. Multicolor flow cytometry (MFC) with availability of newer markers is highly useful in the diagnosis of the plasma cell leukemia. We present an immunophenotypic profile in ten cases of PCL along with their clinical and laboratory findings. Materials and Methods: We retrospectively studied immunophenotypic profile of 10 cases of plasma cell leukemia (out of 4615 cases of hematolymphoid neoplasms) using five parameter, three color flow cytometric analysis. We also studied their clinical presentation and other laboratory findings. Results: Common clinical features at presentation were weakness, bone pain, anemia, thrombocytopenia and osteolytic lesions. Plasma cell population was identified on strong expression of CD38 and co-expression of CD38 and CD138. CD56 was expressed in 44% cases. CD19 and CD20 were negative in all cases. Surface light chain restriction was seen in 50% cases and in remaining 50% cases revealed cytoplasmic light chain restriction. CD117 was expressed in one out of two cases studied. Conclusions: MFC immunophenotyping is highly useful to differentiate Plasma cell leukemia from other chronic lymphoproliferative disorders with plasmacytoid morphology as well as from non-neoplastic reactive PC and co-expression of CD38 and CD138 is a best combination to identify the plasma cells by MFC.
机译：背景：浆细胞白血病（PCL）是浆细胞发育不良的一种罕见但具有侵略性的亚型。已知其表现出高度可变的形态学特征并且可以与其他淋巴样肿瘤相似。具有更新标记的多色流式细胞术（MFC）在浆细胞白血病的诊断中非常有用。我们介绍了十例PCL的免疫表型概况，以及他们的临床和实验室发现。材料与方法：我们采用五参数三色流式细胞术回顾性研究了10例浆细胞白血病（4615例血淋巴肿瘤）的免疫表型特征。我们还研究了他们的临床表现和其他实验室发现。结果：就诊时常见的临床特征是无力，骨痛，贫血，血小板减少和溶骨性病变。在CD38的强表达以及CD38和CD138的共表达下鉴定出浆细胞群。 CD56在44％的病例中表达。在所有情况下，CD19和CD20均为阴性。在50％的病例中观察到表面轻链限制，在其余50％的病例中显示出胞质轻链限制。在研究的每两个案例中有一个表达了CD117。结论：MFC免疫表型对区分浆细胞性白血病与其他具有浆细胞样形态的慢性淋巴细胞增生性疾病以及非肿瘤反应性PC非常有用，CD38和CD138的共表达是通过MFC识别浆细胞的最佳组合。

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