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首页> 外文期刊>Annals of Dermatology >Periadnexal Mucin as an Additional Histopathologic Feature of Chronic Eczematous Dermatitis
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Periadnexal Mucin as an Additional Histopathologic Feature of Chronic Eczematous Dermatitis

机译：Periadnexal粘蛋白作为慢性湿疹性皮炎的附加组织病理学特征

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Background Cutaneous mucinoses are a heterogeneous group of disorders characterized by an abnormal amount of mucin in the skin. However, the pathomechanism of an excessive mucin deposition in the skin is still unknown. Eczematous dermatitis is sub-classified histologically into acute, subacute, and chronic variants. The characteristic histopathologic findings for chronic eczema are variable. However, periadnexal mucin deposition is not known as a feature of chronic eczema. Objective To evaluate the presence of periadnexal mucin deposition in chronic eczematous dermatitis. Methods We analyzed the skin biopsy specimens from 36 patients who were pathologically diagnosed with chronic eczematous dermatitis. Alcian blue, colloidal iron, and periodic acid-Schiff stains were used to evaluate the mucin deposition in histologic sections. Two dermatologists and two dermatopathologists evaluated the degree of mucin deposition using a 4-point scale. Results Various amounts of mucin deposition were observed in the periadnexal area of patients who were diagnosed with chronic eczema. Mucin deposition was more visible after staining with mucin-specific stains. Evaluation of the staining analysis scores revealed that the staining intensities were significantly higher in patients with chronic eczema than age- and site-matched controls (normal, acute to subacute eczema, and psoriasis vulgaris). Conclusion Periadnexal mucin (secondary mucinoses) may be an additional finding of chronic eczematous dermatitis.
机译：背景技术皮肤粘蛋白是一组异质性疾病，其特征是皮肤中粘蛋白的含量异常。然而，尚不清楚皮肤中粘蛋白沉积过多的致病机理。湿疹性皮炎在组织学上分为急性，亚急性和慢性变异。慢性湿疹的特征性组织病理学发现是可变的。然而，肾周炎性粘膜沉积不被认为是慢性湿疹的特征。目的评估慢性湿疹性皮炎中周围黏膜黏蛋白沉积的存在。方法我们分析了36例经病理诊断为慢性湿疹性皮炎的患者的皮肤活检标本。使用阿尔辛蓝，胶体铁和高碘酸席夫（Schiff）染色来评估组织切片中的粘蛋白沉积。两名皮肤科医生和两名皮肤病理学家使用4分制量表评估了粘蛋白沉积的程度。结果在被诊断为慢性湿疹的患者的周围区域观察到各种粘蛋白沉积。用粘蛋白特异性污渍染色后，粘蛋白沉积更明显。对染色分析评分的评估显示，慢性湿疹患者的染色强度显着高于年龄和部位匹配的对照（正常，急性至亚急性湿疹和寻常型牛皮癣）。结论前列腺粘液（继发性粘液）可能是慢性湿疹性皮炎的另一个发现。

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