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首页> 外文期刊>Indian Journal of Virology >Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations
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Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations

机译：突尼斯莫纳斯提尔地区儿童的肠道病毒中枢神经系统感染：诊断，脑脊液实验室检查结果和临床表现

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摘要

Human enteroviruses (HEV) are one of the major causes of central nervous system (CNS) infections in pediatrics. A prospective study was conducted to assess the epidemiological, clinical, and laboratory characteristics of enterovirus (EV) infections of the CNS in children under 15-years-old, suspected of having viral CNS infections and admitted to the Pediatric Department of Monastir University Hospital, Tunisia. Enteroviral RNA was detected by 5′ NCR nested RT-PCR assay in 33?% (20 out of 60) of cerebrospinal fluid specimens, whereas only six samples (10?%) were EV positive in cell culture. EV-positive patients were clustered according to their clinical manifestations, predominantly diagnosed as aseptic meningitis (65?%) and meningoencephalitis (20?%). Fever, headache, vomiting, and neck stiffness were the most pronounced symptoms. Pleocytosis with the predominance of lymphocytes was observed in 60?% of EV positive specimens. Although patients suffering from EV infections were encountered throughout the year, most occurred during spring and summer months. Using VP1-2A nested RT-PCR and sequence analysis, three of the 20 positive HEV were identified as Echovirus (E)-9. This is the first report of a cluster of aseptic meningitis cases caused by E-9 in Monastir.
机译：人肠病毒（HEV）是小儿中枢神经系统（CNS）感染的主要原因之一。进行了一项前瞻性研究，以评估15岁以下怀疑患有病毒中枢神经系统感染并已进入莫纳斯提尔大学医院儿科的儿童的中枢神经系统肠道病毒（EV）感染的流行病学，临床和实验室特征，突尼斯。通过5'NCR巢式RT-PCR分析检测到了33％（60个中的20个）脑脊液标本中的肠病毒RNA，而在细胞培养中只有6个样品（10％）是EV阳性的。 EV阳性患者根据临床表现分组，主要诊断为无菌性脑膜炎（65％）和脑膜脑炎（20 %%）。发烧，头痛，呕吐和颈部僵硬是最明显的症状。在60％的EV阳性标本中观察到淋巴细胞以淋巴细胞为主。尽管全年都遇到患有EV感染的患者，但大多数发生在春季和夏季。使用VP1-2A嵌套式RT-PCR和序列分析，将20例阳性HEV中的3例鉴定为Echovirus（E）-9。这是在莫纳斯提尔由E-9引起的一系列无菌性脑膜炎病例的首次报道。

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