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首页> 外文期刊>Journal of Medical Virology >Comparison of Clinical Manifestations, Outcomes and Cerebrospinal Fluid Findings Between Herpes Simplex Type 1 and Type 2 Central Nervous System Infections in Adults
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Comparison of Clinical Manifestations, Outcomes and Cerebrospinal Fluid Findings Between Herpes Simplex Type 1 and Type 2 Central Nervous System Infections in Adults

机译：成人单纯疱疹1型和2型中枢神经系统感染的临床表现，预后和脑脊液发现的比较

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摘要

In previous reports on the viral causes of central nervous system (CNS) infections, it has been generally recognized that HSV-1 is a major cause of encephalitis, while HSV-2 is the predominant cause of aseptic meningitis in adults. To examine this matter, the clinical characteristics in the two types of HSV CNS infections were investigated. In a retrospective cohort study which included all adult patients (>16 years) between January 1999 and December 2013 in a 2,700-bed tertiary care hospital, all the patients in whom PCR of the CSF for HSV was positive were identified. Ninety-five patients with positive CSF PCR results for HSV were included, 21 with HSV-1 and 74 with HSV-2. Many patients with HSV-1 had encephalitis (13/21, 61.9%), whereas most patients with HSV-2 had meningitis (62/74, 83.8%). However, HSV-1 and HSV-2 accounted for similar proportion of patients with HSV encephalitis (13/25, 52.0% vs. 12/25, 48.0%). Neurological sequelae were more frequent among patients with HSV-1 (9/21, 42.9% vs. 6/74, 8.1%; P= 0.001). The present study suggests that HSV-2 is not only a major cause of aseptic meningitis, but also it may cause serious manifestation as HSV-1 encephalitis in adults.
机译：在以前关于中枢神经系统（CNS）感染的病毒原因的报告中，人们普遍认识到HSV-1是脑炎的主要病因，而HSV-2是成人无菌性脑膜炎的主要病因。为了检查该问题，研究了两种类型的HSV CNS感染的临床特征。在一项回顾性队列研究中，该研究纳入了1999年1月至2013年12月在一家拥有2700张床位的三级医院中的所有成年患者（> 16岁），确定了所有HSV CSF PCR阳性的患者。包括95例HSV的CSF PCR结果均为阳性的患者，其中21例为HSV-1，74例为HSV-2。许多HSV-1患者患有脑炎（13 / 21，61.9％），而大多数HSV-2患者患有脑膜炎（62 / 74，83.8％）。但是，HSV-1和HSV-2在HSV脑炎患者中所占比例相似（13 / 25，52.0％，而12 / 25，48.0％）。 HSV-1患者中神经系统后遗症的发生率更高（9 / 21，42.9％; 6 / 74，8.1％; P = 0.001）。本研究表明，HSV-2不仅是无菌性脑膜炎的主要病因，而且还可能引起成人HSV-1脑炎的严重表现。

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