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首页> 外文期刊>Infectious Diseases and Therapy >Consider Syphilis in Case of Lymphopenia in HIV-Infected Men Who Have Sex with Men (MSM): A Single-center, Retrospective Study
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Consider Syphilis in Case of Lymphopenia in HIV-Infected Men Who Have Sex with Men (MSM): A Single-center, Retrospective Study

机译：在艾滋病毒感染的男性患者中发生淋巴细胞减少症时考虑梅毒（MSM）：一项单中心回顾性研究

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IntroductionThe way syphilis affects the immunologic and virologic parameters of a human immunodeficiency virus (HIV) infection remains controversial. The aim of this study was to investigate the impact of syphilis infection on lymphocyte and lymphocyte subset counts as well as viral load in HIV-infected patients. MethodsAll HIV-infected patients attending the outpatient clinic for infectious diseases of Hannover Medical University Hospital diagnosed with syphilis between 2009 and 2016 were retrospectively evaluated for changes in total lymphocyte, B cell, CD3+ T cell, CD4+ and CD8+ T cell counts as well as in HIV viral load. These parameters were assessed at three different time points, i.e., 3–6?months before, at diagnosis and 3–6?months after treatment of syphilis. ResultsEighty-four HIV-infected patients, all with early syphilis, were identified. The vast majority were men who have sex with men (MSM), and 80% were receiving antiretroviral therapy (ART). Syphilis was associated with a significant reduction in the total lymphocyte count and counts of all studied lymphocyte subsets, including CD4+ T cells, whose percentage among lymphocytes did not change. No significant changes in HIV viral load were observed at any of the studied time points. Further, antibiotic treatment of syphilis restored lymphocyte counts back to pretreatment levels. ConclusionSyphilis induces a relative non-CD4+ T cell-specific lymphopenia in HIV-infected patients. Our data suggest that serologic testing for syphilis should be considered in HIV-infected MSM in case of an otherwise unexplained drop in total lymphocyte count.
机译：简介梅毒影响人类免疫缺陷病毒（HIV）感染的免疫学和病毒学参数的方式仍存在争议。这项研究的目的是调查梅毒感染对HIV感染患者的淋巴细胞和淋巴细胞亚群计数以及病毒载量的影响。方法回顾性分析2009年至2016年在汉诺威医科大学附属医院传染病门诊就诊并患有梅毒的所有HIV感染患者的总淋巴细胞，B细胞，CD3 + T细胞，CD4 +和CD8 + T细胞计数的变化。 HIV病毒载量。这些参数是在三个不同的时间点进行评估的，即在梅毒诊断之前，诊断后3-6个月和梅毒治疗后3-6个月。结果确定了84例均患有早期梅毒的HIV感染患者。绝大多数是与男性发生性关系的男性（MSM），其中80％正在接受抗逆转录病毒疗法（ART）。梅毒与总淋巴细胞计数和所有研究的淋巴细胞亚群（包括CD4 + T细胞，其淋巴细胞百分比未改变）的计数显着减少有关。在任何研究的时间点均未观察到HIV病毒载量的显着变化。此外，梅毒的抗生素治疗使淋巴细胞恢复至治疗前水平。结论梅毒可在HIV感染患者中引起相对的非CD4 + T细胞特异性淋巴细胞减少。我们的数据表明，如果无法解释的总淋巴细胞计数下降，应考虑在HIV感染的MSM中进行梅毒的血清学检测。

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