• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infectious Diseases and Therapy >Prevalence of Clostridium Difficile -Associated Diarrhoea in Hospitalised Patients (Results of a Russian Prospective Multicentre Study)
【24h】

Prevalence of Clostridium Difficile -Associated Diarrhoea in Hospitalised Patients (Results of a Russian Prospective Multicentre Study)

机译：住院患者艰难梭菌相关性腹泻的患病率（一项俄罗斯前瞻性多中心研究的结果）

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

IntroductionThe objective of the study was to evaluate the prevalence of Clostridium difficile -associated diarrhoea (CDAD) among hospitalised patients with antibiotic-associated diarrhoea (AAD) in general and by specific types of medical care and hospital units. MethodsA prospective, cross-sectional, non-interventional, multicentre study. The main inclusion criteria were: patient age?≥?18?years, hospital stay of at least 48?h, current antibiotic therapy or antibiotic therapy within the previous 30?days, loose stools (Bristol stool types 5–7 and stool frequency?≥?3 within?≤?24 consecutive hours or exceeding normal for the patient) and signed informed consent form. The stool sample was taken to the local (study site) microbiology laboratory for detection of glutamate dehydrogenase (GDH) and toxins A/B using enzyme immunoassay (EIA) stool test. ResultsFrom April 2016 to April 2017, a total of 1245 patients from 12 large hospitals were enrolled in the study. Data on 81 patients were excluded from the analysis for different reasons. Data on 1164 patients (45.2% males and 54.8% females) with a mean age of 54.9?years (range 18–95?years) were analysed. Length of hospitalisation was 2–188?days (median, 8?days). The EIA stool test showed CDAD-positive results in 21.7% (253/1164) patients. The patients were from surgery units (546/1164), internal medicine units (510/1164) and intensive care units (108/1164). The prevalence of CDAD among patients from surgery, internal medicine and intensive care units was 26.2, 17.8 and 17.6%, respectively. Oncology, gastroenterology, septic surgery, oncohaematology and general medical hospital units accounted for more than 75% of all patients included; the prevalence of CDAD by those hospital units was 11.3, 15.0, 39.2, 17.6, and 27.2%, respectively. The proportion of GDH-positive and toxin A/B-negative patients by the rapid stool test result was 16.8% (196/1164). The prevalence of CDAD varied widely between the hospitals (from 0 to 44.3%). ConclusionsThe prevalence of CDAD among hospitalised patients with AAD in this study was 21.7% (95% confidence interval: 14.8 and 28.7%). The percentage of CDAD varied widely between hospitals and by specific types of medical care and hospital units.
机译：引言本研究的目的是评估住院的抗生素相关性腹泻（AAD）患者的总体艰难梭菌相关性腹泻（CDAD）的患病率，并按特定类型的医疗机构和医院单位进行评估。方法：一项前瞻性，横断面，非干预，多中心研究。主要入选标准为：患者年龄≥18岁，住院时间至少48小时，当前的抗生素治疗或过去30天之内的抗生素治疗，大便稀少（布里斯托尔大便类型5-7和大便次数？连续24小时内≥≥3，或患者超出正常水平）并签署知情同意书。粪便样本被带到当地（研究地点）微生物学实验室，使用酶免疫法（EIA）粪便测试法检测谷氨酸脱氢酶（GDH）和毒素A / B。结果从2016年4月到2017年4月，共有12家大型医院的1245名患者参加了研究。由于不同的原因，将81例患者的数据排除在分析之外。分析了1164例平均年龄为54.9岁（18-95岁）的患者（男性45.2％，女性54.8％）的数据。住院时间为2–188天（中位数为8天）。 EIA粪便测试显示21.7％（253/1164）患者的CDAD阳性结果。患者来自手术室（546/1164），内科室（510/1164）和重症监护室（108/1164）。来自外科，内科和重症监护病房的患者中CDAD的患病率分别为26.2、17.8和17.6％。肿瘤科，肠胃病科，化脓外科，肿瘤血液科和普通内科医院单位占所有患者的75％以上;这些医院单位的CDAD患病率分别为11.3％，15.0％，39.2％，17.6和27.2％。快速粪便检测结果显示，GDH阳性和毒素A / B阴性的患者比例为16.8％（196/1164）。医院之间CDAD的患病率差异很大（从0到44.3％）。结论本研究中住院的AAD患者中CDAD的患病率为21.7％（95％置信区间：14.8和28.7％）。 CDAD的百分比在各医院之间以及不同类型的医疗机构和医院单位之间差异很大。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号