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首页> 外文期刊>Infection and Drug Resistance >Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance
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Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance

机译：氟喹诺酮类抗生素对游动巴贝斯菌和小巴贝斯菌，对动物和人畜共患病具有重要意义的血液寄生虫的抑制作用

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Aim: This study aimed to evaluate the inhibitory effects of fluoroquinolone antibiotics, including enrofloxacin, enoxacin, trovafloxacin, norfloxacin, and ofloxacin, on the in vitro and in vivo growth of Babesia divergens and Babesia microti parasites, respectively. Materials and methods: The in vitro and in vivo inhibitory effects of fluoroquinolone antibiotics against B. divergens and B. microti , respectively were evaluated using fluorescence-based assay. Additionally, combination therapies of highly effective fluoroquinolone antibiotics (enrofloxacin, enoxacin, and trovafloxacin) with diminazene aceturate, luteolin, or pyronaridine tetraphosphate were tested on the in vitro cultures of B. divergens . Results: Enrofloxacin, trovafloxacin, and enoxacin were the most effective fluoroquinolones against the in vitro growth of B. divergens , followed by norfloxacin and ofloxacin. Furthermore, a combination of enoxacin or trovafloxacin with either diminazene aceturate, luteolin, or pyronaridine tetraphosphate significantly enhanced the inhibitory effect on the growth of B. divergens in in vitro cultures. In mice infected by B. microti , enoxacin and diminazene aceturate combination therapy exhibited a potential antibabesial effect. Conclusion: These results suggest that safe and cheap fluoroquinolone, such as enoxacin, might be used for the treatment of clinical cases caused by Babesia spp. in animals or humans.
机译：目的：本研究旨在评估氟喹诺酮抗生素（包括恩诺沙星，依诺沙星，曲伐沙星，诺氟沙星和氧氟沙星）对巴氏杆菌多样性和巴贝斯微虫的体外和体内生长的抑制作用。材料和方法：使用基于荧光的试验评估了氟喹诺酮类抗生素对B. divergens和B. microti的体外和体内抑制作用。另外，在多形芽孢杆菌的体外培养上测试了高效氟喹诺酮类抗生素（恩诺沙星，依诺沙星和曲伐沙星）与醋酸二咪唑酯，木犀草素或吡咯烷四氢呋喃的组合疗法。结果：Enrofloxacin，Trovafloxacin和Enoxacin是对抗曲霉芽孢杆菌体外生长的最有效的氟喹诺酮类药物，其次是诺氟沙星和氧氟沙星。此外，在体外培养中，依诺沙星或曲伐沙星与醋酸二咪唑，木犀草素或四磷酸吡喃二苯胺的组合显着增强了对B. divergens生长的抑制作用。在感染小肠芽孢杆菌的小鼠中，依诺沙星和醋酸地米那嗪联合治疗表现出潜在的抗婴儿作用。结论：这些结果表明，安全廉价的氟喹诺酮，如依诺沙星，可用于治疗由巴贝斯虫引起的临床病例。在动物或人类中。

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