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首页> 外文期刊>Infection and Drug Resistance >Antibiotic sensitivities of coagulase-negative staphylococci and Staphylococcus aureus in hip and knee periprosthetic joint infections: does this differ if patients meet the International Consensus Meeting Criteria?
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Antibiotic sensitivities of coagulase-negative staphylococci and Staphylococcus aureus in hip and knee periprosthetic joint infections: does this differ if patients meet the International Consensus Meeting Criteria?

机译：髋关节和膝关节假体周围感染中凝固酶阴性葡萄球菌和金黄色葡萄球菌的抗生素敏感性：如果患者符合国际共识会议标准，这会有所不同吗？

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Introduction: Coagulase-negative staphylococci (CoNS) are the main pathogens responsible for prosthetic joint infections (PJIs). As normal inhabitants of human skin, it is often difficult to define if they are contaminants, or if they have an active role in initiating infection. This study aims to evaluate differences in CoNS organisms ( Staphylococcus hominis , Staphylococcus capitis , Staphylococcus haemolyticus , Staphylococcus warneri ) and Staphylococcus aureus in terms of isolation rate and antimicrobial susceptibility from patients who met the International Consensus Meeting (ICM) criteria for PJIs and those who did not. Methods: Staphylococci isolates from January 2014 to December 2015 retrieved from patients undergoing revision joint arthroplasty were classified in accordance with criteria established by the ICM of Philadelphia. Results: As per the consensus classification, 50 CoNS and 39 S. aureus infections were recognized as pathogens, while 16 CoNS and four S. aureus were considered as contaminants. Frequency of isolation of S. aureus was significantly higher in infected patients than in those without infection, while no significant differences were observed among CoNS. Resistance to levofloxacin, erythromycin, gentamicin trimethoprim/sulfamethoxazole, and rifampicin was significantly more frequent in S. haemolyticus than in the other species, as well as resistance to erythromycin and gentamicin in S. hominis . In comparison to S. aureus , CoNS were significantly more resistant to daptomycin and gentamicin and more susceptible to rifampicin. Conclusion: CoNS, other than Staphylococcus epidermidis , are frequently isolated from PJIs, and their infective role and antimicrobial susceptibility need to be assessed on an individual patient basis. S. haemolyticus seems to emerge as responsible for PJI in a large volume of patients, and its role needs to be further investigated, also considering its pattern of resistance.
机译：简介：凝固酶阴性葡萄球菌（CoNS）是造成假体关节感染（PJI）的主要病原体。作为人类皮肤的正常居民，通常很难确定它们是否是污染物，或者是否在引发感染中起积极作用。这项研究旨在评估CoNS微生物（人葡萄球菌，葡萄球菌，溶血性葡萄球菌，华氏葡萄球菌）和金黄色葡萄球菌在分离率和对PJI符合国际共识会议（ICM）标准的患者的抗菌药敏性方面的差异。没有。方法：根据费城ICM建立的标准，对2014年1月至2015年12月从接受翻修关节置换术的患者中分离出的葡萄球菌进行分类。结果：按照共识分类，将50例CoNS和39例金黄色葡萄球菌感染识别为病原体，而16例CoNS和4例金黄色葡萄球菌被视为污染物。感染患者中金黄色葡萄球菌的分离频率显着高于未感染患者，而CoNS之间未观察到显着差异。溶血链球菌对左氧氟沙星，红霉素，庆大霉素甲氧苄氨嘧啶/磺胺甲恶唑和利福平的抗药性比其他物种明显更高，而对人红霉素对红霉素和庆大霉素的抗药性也更高。与金黄色葡萄球菌相比，CoNS对达托霉素和庆大霉素的抵抗力明显更高，对利福平更敏感。结论：除表皮葡萄球菌外，CoNS经常从PJI中分离出来，其感染作用和抗菌药敏性需要根据患者情况进行评估。溶血链球菌似乎在大量患者中成为造成PJI的原因，其作用还需要进一步研究，同时还要考虑其耐药性模式。

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