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首页> 外文期刊>Influenza and other respiratory viruses. >Differential use of antivirals for treatment of patients with influenza A(H1N1)pdm09 in Germany
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Differential use of antivirals for treatment of patients with influenza A(H1N1)pdm09 in Germany

机译：在德国区别使用抗病毒药治疗甲型H1N1流感患者

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AbstractBackgroundThe World Health Organization recommends early antiviral treatment for patients with severe influenza illness or those at increased risk for severe illness.ObjectivesThe aim of this study was to determine the proportion of cases with laboratory-confirmed A(H1N1)pdm09 infection that have been treated with antivirals in Germany during the pandemic (H1N1) 2009 and to investigate factors associated with the use of antivirals.MethodsWe analyzed cases with laboratory-confirmed A(H1N1)pdm09 infection notified to national health authorities in Germany between week 29/2009 and week 17/2010 using multivariable logistic regression. Severity of disease was defined by pneumonia or death.Results and conclusionsOf 160 804 cases with laboratory-confirmed A(H1N1)pdm09 infection, 22% were treated with antivirals. Cases with severe disease were more likely to be treated with antivirals than cases without severe disease (odds ratio = 1·66; 95% confidence interval: 1·46–1·89). In the group with at least one underlying medical condition, only children aged between 1 and 4 years had significant lower odds for receiving antiviral treatment compared with cases in the age group 15 to 49 years (odds ratio = 0·75; 95% confidence interval: 0·6–0·94). In conclusion, the implementation of international recommendations on use of antivirals differed according to the age of patients in Germany during the pandemic (H1N1) 2009. This indicates that the potential of antivirals to prevent severe influenza might not have been fully exhausted. The reasons leading to the observed differences in patient management need to be investigated.
机译：摘要背景世界卫生组织（World Health Organization）建议对患有严重流感或严重疾病风险较高的患者进行早期抗病毒治疗。方法：我们分析了2009年大流行（H1N1）期间德国的抗病毒药物，并调查了与抗病毒药物使用相关的因素。 2010年使用多元logistic回归。结果和结论在160例经实验室确诊的A（H1N1）pdm09感染病例中，有22％接受了抗病毒药物治疗。与没有严重疾病的病例相比，具有严重疾病的病例更有可能接受抗病毒药物治疗（优势比= 1·66; 95％置信区间：1·46-1·89）。在具有至少一种基本医疗状况的组中，与年龄在15至49岁的年龄组相比，只有1至4岁的儿童接受抗病毒治疗的几率明显较低（几率= 0·75;置信区间为95％ ：0·6-0·94）。总之，根据2009年H1N1大流行期间德国患者的年龄，使用抗病毒药物的国际建议的实施情况会有所不同。这表明抗病毒药物预防严重流感的潜力可能尚未完全耗尽。需要调查导致观察到的患者管理差异的原因。

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