• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Influenza and other respiratory viruses. >Differential use of antivirals for treatment of patients with influenza A(H1N1)pdm09 in Germany
【24h】

Differential use of antivirals for treatment of patients with influenza A(H1N1)pdm09 in Germany

机译：在德国区别使用抗病毒药治疗甲型H1N1流感患者

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The World Health Organization recommends early antiviral treatment for patients with severe influenza illness or those at increased risk for severe illness. Objectives: The aim of this study was to determine the proportion of cases with laboratory-confirmed A(H1N1)pdm09 infection that have been treated with antivirals in Germany during the pandemic (H1N1) 2009 and to investigate factors associated with the use of antivirals. Methods: We analyzed cases with laboratory-confirmed A(H1N1)pdm09 infection notified to national health authorities in Germany between week 29/2009 and week 17/2010 using multivariable logistic regression. Severity of disease was defined by pneumonia or death. Results and conclusions: Of 160 804 cases with laboratory-confirmed A(H1N1)pdm09 infection, 22% were treated with antivirals. Cases with severe disease were more likely to be treated with antivirals than cases without severe disease (odds ratio = 1·66; 95% confidence interval: 1·46-1·89). In the group with at least one underlying medical condition, only children aged between 1 and 4 years had significant lower odds for receiving antiviral treatment compared with cases in the age group 15 to 49 years (odds ratio = 0·75; 95% confidence interval: 0·6-0·94). In conclusion, the implementation of international recommendations on use of antivirals differed according to the age of patients in Germany during the pandemic (H1N1) 2009. This indicates that the potential of antivirals to prevent severe influenza might not have been fully exhausted. The reasons leading to the observed differences in patient management need to be investigated.
机译：背景：世界卫生组织建议对患有严重流感疾病或罹患严重疾病风险较高的患者进行早期抗病毒治疗。目的：本研究的目的是确定在2009年大流行（H1N1）期间在德国接受抗病毒药物治疗的实验室确诊的A（H1N1）pdm09感染病例的比例，并调查与使用抗病毒药物相关的因素。方法：我们使用多元逻辑回归分析了在2009年29 /周至17/2010周之间已通知德国国家卫生部门的实验室确诊的A（H1N1）pdm09感染病例。疾病的严重程度由肺炎或死亡定义。结果与结论：在实验室确认的A（H1N1）pdm09感染的160804例患者中，有22％接受了抗病毒药物治疗。与没有严重疾病的病例相比，具有严重疾病的病例更有可能接受抗病毒药物治疗（优势比= 1·66; 95％置信区间：1·46-1·89）。在具有至少一种基础疾病的组中，只有1至4岁的儿童接受抗病毒治疗的几率比15至49岁年龄组的患病率低（优势比= 0·75;置信区间为95％） ：0·6-0·94）。总之，根据2009年H1N1大流行期间德国患者的年龄，使用抗病毒药物的国际建议的实施情况会有所不同。这表明抗病毒药物预防严重流感的潜力可能尚未完全耗尽。需要对导致观察到的患者管理差异的原因进行调查。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号